The Effect of Omega-3 Supplementation on Serum Inflammatory Factors in Hemodialysis Patients
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 20, Issue 7
Abstract
Background: The level of inflammatory factors such as tumor necrosis factor-alfa (TNF-α) and C-reactive protein (CRP) is increased in ESRD patients and is associated with incremental mortality in these patients. Omega-3 is known as a regulator of inflammatory system. The aim of this study is to evaluate the effect of omega-3 supplementation on TNF-α and CRP level in ESRD patients. Methods: In this randomized _ controlled double-blind clinical trial, 54 ESRD patients were evaluated in two hemodialysis centers of Isfahan university hospitals. TNF-α and high specific-CRP (hs-CRP) were measured. In the experimental group, Patients were treated with Omega-3 capsules (1 gram capsules- Making factory Zahravi- containing Eicosapentanoic 180 mg and Dosahexanoic 120 mg) three capsules per day (3 g/day ) and the control group received placebo capsules manufactured by the Zahravi with the same shape and size for 6 consecutive months. Results: There were no differences in CRP and TNF-α levels in the beginning and the end of study between two groups (P > 0.05). Conclusion: We conclude that using 3 g of omega-3 per day for 6 consecutive months caused no significant effect on serum levels of TNF-α and CRP in the heamodialysis population .Further studies with larger numbers of patients and longer duration of treatment are recommended.
Authors and Affiliations
Yaser Salehi, Firouzeh Moinzadeh, Mojgan Mortazavi, Mohsen Hoseini, Shahaboddin Dolatkhah, Shahram Taheri, Amirhosein Salehi
Keywords
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- EP ID EP311443
- DOI 10.9734/BJMMR/2017/27659
- Views 51
- Downloads 0
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