The Effect of Preemptive Oral Celecoxib on Pain Reduction and Opioid Consumption during Elective Herniorrhaphy
Journal Title: Enliven: Journal of Anesthesiology and Critical Care Medicine - Year 2016, Vol 3, Issue 1
Abstract
Introduction Pain control is an important aspect in postoperative care. While opioids proved excellent analgesia undesirable side effects such as respiratory depression, nausea and vomiting, constitute major limitation. As a result, many surgical centers used NSAIDs for controlled acute pain of surgery. Celecoxib is NSAIDs that inhibits cox2, but it does not have GI side effect and coagulopathy disorder. The aim of this study was to determine the effect of preemptive celexib on pain score reduction and opioid consumption after herniorrhaphy. Material and Method This is a randomised double blinded clinical trial study which performed in Imam Ali and Khatam hospital in zahedan. 76 patients scheduled for elective herniorrhaphy were enroled in this study. Patients were divided into 2GROUPS; celexib group (n=38) and placebo group (n=38). Drugs (placebo or 200mg celexib) were given (oraly) 2 hours before operation to patients. All patients general anesthetized with midazolam (1-2mg), fentanyl (1-2μg/kg) for premedication; nesdonal (4-6mg/kg) and atracorioum (0.5mg/kg) for induction and propofol (100-200 μg/kg) for maintenance. Then pain score (vas score), heart rate, blood pressure was recorded in 2Snd, 6th, 12th and 24th hours after tracheal extubation. Pain was treated with morphin 0.1 mg /kg in patients with vas score >4. Total Opioid consumption was recorded for 24hours. Results Mean painless time in celexib group was higher than placebo group {12.7±9.8 to 5.38±8.3 (p=0.04)} and mean pain score of 2nd hour in the celexib group was lower than placebo {2.2±2.2 to 5.7±3.5 (p=0.003)}. The mean opioid used in celexib group was lower than placebo group {5.33±6.1 to 11.15±7.1 (p=0.02)}. But difference in mean of HR and BP between two groups wasn't significant. Conclusion Preemptive clexib to be able to reduce pain score and consumption of opioid after hernirrhaphy.
Authors and Affiliations
Mahjoubifard Maziar, Enayati Hasan, Noori Noor Mohammad, Shaikh Mahdy, Fard Alireza Jahangiri
Keywords
Related Articles
- EP ID EP625911
- DOI -
- Views 176
- Downloads 1
Comparison of the Use of Epidrum with Air or Saline for Identifying the Epidural Space
Background Identification of the epidural space has a critical role in epidural anesthesia. Epidrum® has been a recently developed air operated device used for identifying the epidural space. This study compares the usag...
Anesthetic Management in a Pediatric Patient Posted for Bronchoscopy
Anesthetic management in a pediatric patient posted for an impacted foreign body in bronchus is quite challenging, Hemorrhage, Tension pneumothorax during rigid bronchoscopy for foreign body removal is a rare but life th...
Stellate Ganglion Block Reduces the Radicular Pain and Salivary Alpha-Amylase Activity in Patients with Cervical Spondylosis
Background The effects of stellate ganglion block (SGB) on radicular pain associated with cervical spondylosis remain to be clarified. So we measured salivary alpha-amylase which reflects sympathetic nerve activity under...
Difficult Airway due to Retropharyngeal Hematoma after Stabbing to the Neck
Reports of retropharyngeal hematoma have been scarce in the anesthesiology literature. We report a patient whose trachea was difficult to intubate due to retropharyngeal hematoma after stabbing to the neck. A woman with...
Comparative Study between Levobupivacine versus Levobupivacaine Plus Dexmedetomidine for Transversus Abdominis Plane Block ?TAP? in Post-Operative Pain Management after Abdominoplasty
Aim of the work Transversus abdominis plane “TAP’’ block has been reported to be effective for post-operative analgesia for patients undergoing surgery involving abdominal wall incision by blocking anterior branches of t...