The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats
Journal Title: The Medical Bulletin of Haseki - Year 2019, Vol 57, Issue 3
Abstract
Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7. Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively). Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts.
Authors and Affiliations
Erkan Orhan, İlsun Özkaya Aka, Merve Yüzbaşıoğlu, Burçin Yavuz, Erem Bilensoy, Ayşe Kuruüzüm Uz
Keywords
Related Articles
- EP ID EP50764
- DOI 10.4274/haseki.galenos.2018.4533
- Views 284
- Downloads 0
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