The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats
Journal Title: The Medical Bulletin of Haseki - Year 2019, Vol 57, Issue 3
Abstract
Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7. Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively). Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts.
Authors and Affiliations
Erkan Orhan, İlsun Özkaya Aka, Merve Yüzbaşıoğlu, Burçin Yavuz, Erem Bilensoy, Ayşe Kuruüzüm Uz
Keywords
Related Articles
- EP ID EP50764
- DOI 10.4274/haseki.galenos.2018.4533
- Views 244
- Downloads 0
Comparison of Complicatıons Following Laparoscopic Radical and Simple Nephreoctomy Using the Claviendindo Clasification
Aim: In this article, we aimed to compare the complications occurring after laparoscopic radical (LRN) and simple nephrectomy (LSN). Methods: After obtaining local ethics committee approval, we analyzed the records of a...
Urological Complications and Management After Gynecological Operations
Aim: We aimed to evaluate the urological complications of gynecologic operations in a tertiary academic center and to evaluate the methods of treatment of these complications. Methods: Files of all patients, who underwe...
Macular Optical Coherence Tomography Angiography Parameters in Central Retinal Vein Occlusion and Differentiation of Ischemic and Non-Ischemic Types
Aim: To evaluate the macular microvascular parameters in central retinal vein occlusion (CRVO) and to differentiate its ischemic and non-ischemic types. Methods: This study included 32 affected and 32 unaffected eyes of...
Acute Kidney Injury in a Patient Receiving Antimalarial Therapy: A Case Report
In this article, we present a case of Plasmodium falciparum malaria in a male patient who developed acute kidney injury during antimalarial treatment. A 38-years-old Turkish male patient was admitted to the emergency dep...
The Effect of Residual Renal Function on Clinical and Laboratory Parameters in Peritoneal Dialysis Patients
Aim: To evaluate the effects of residual renal function (RRF) on anemia treatment, phosphorus control and nutritional parameters in peritoneal dialysis (PD) patients. Methods: PD patients were retrospectively analyzed....