The Effect of Quercus coccifera L. Extract on the Necrosis of Random-pattern Skin Flaps in Rats
Journal Title: The Medical Bulletin of Haseki - Year 2019, Vol 57, Issue 3
Abstract
Aim: Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability. Methods: Eighteen Wistar rats were used. Random-pattern skin flaps, 9x3 cm in size, were applied on rats back and then the rats were divided into three groups. Following surgery, 2 cc of nitrofurazone cream and 2 cc of Q. coccifera L. water extract were applied daily in groups 2 and 3, respectively. Group 1 received no treatment after surgery. The percentage of necrosis on the flaps was calculated and histopathological examination of the tissue samples was made on day 7. Results: The mean percentage of necrosis was 44.7%, 42.5% and 21.8% group 1, 2 and 3, respectively. The percentage of necrosis was statistically significantly lower in group 3 than in groups 1 and 2 (p<0.001 and p<0.00, respectively). Neutrophil score was found to be significantly lower in group 3 than in groups 1 and 2 (p=0.002 and p=0.002, respectively). Conclusions: Necrosis of skin flaps was decreased through application of Q. coccifera extracts.
Authors and Affiliations
Erkan Orhan, İlsun Özkaya Aka, Merve Yüzbaşıoğlu, Burçin Yavuz, Erem Bilensoy, Ayşe Kuruüzüm Uz
Keywords
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- EP ID EP50764
- DOI 10.4274/haseki.galenos.2018.4533
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