The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease
Journal Title: Open Veterinary Journal - Year 2016, Vol 6, Issue 2
Abstract
Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin - converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have distinct kidney protective effects is unknown; it is therefore hypothesized that renal diets and enalapril or benazepril have different beneficial effects in proteinuric CKD dogs. Forty-four dogs with proteinuric CKD (IRIS stages 1-4) were enrolled in the study and were fed renal diet for 30 days. Thereafter, they were randomly assigned to one of 2 groups. Dogs in group A (n=22) received enalapril (0.5 mg/kg, q12h) and in group B (n=22) benazepril (0.5 mg/kg, q24h); in both groups, dogs were fed the same renal diet. After randomization, dogs were monitored for 120 days. Body weight and body condition score (BCS), serum concentrations of creatinine, blood urea nitrogen (BUN), albumin and total proteins, and urine protein-to-creatinine (UPC) ratio were compared at different time-points. After 30 days of renal diet, creatinine, BUN and UPC ratio decreased significantly (p<0.0001). Compared to randomization, body weight, BCS, albumin, total proteins, creatinine and BUN did not vary during follow-up in the 44 dogs and differences between group A and B were not observed. However, the UPC ratio of group A at day 60, 90 and 150 was significantly lower than in group B and compared to randomization (p<0.05). In group B it did not vary overtime. It is concluded that the renal diet is beneficial to decrease creatinine, BUN and UPC ratio in proteinuric CKD dogs. Enalapril further ameliorates proteinuria if administered along with renal diet.
Authors and Affiliations
A. Zatelli| Medical Consultancy Services, G. Calì Street 60, TBX1424 TàXbiex, Malta, X. Roura| Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Spain, P. D’Ippolito| Medical Consultancy Services, G. Calì Street 60, TBX1424 TàXbiex, Malta, M. Berlanda| Department of Animal Medicine, Production and Health, viale dell’Università 16, 35020 Legnaro (PD), University of Padova, Italy, E. Zini| Department of Animal Medicine, Production and Health, viale dell’Università 16, 35020 Legnaro (PD), University of Padova, Italy, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland, Istituto Veterinario di Novara, Strada Provinciale 9, 28060 Granozzo con Monticello (NO), Italy
Keywords
Related Articles
- EP ID EP9375
- DOI -
- Views 403
- Downloads 25
The physicochemical properties and antioxidative potential of raw thigh meat from broilers fed a dietary medicinal herb extract mixture
A 6-wk feeding study was conducted to evaluate the antioxidative potential, indices such as quality of the thigh meat and liver of broiler chickens fed with a dietary medicinal herb extract mixture (HEM, consisting: Ira...
Clinical and ultrasonographic findings of some ocular conditions in sheep and goats
This study was carried out to describe the ultrasonographic findings in relation to the clinical symptoms of some common ocular conditions in sheep and goats. Fifty animals (32 goats and 18 sheep) with different ocular...
Lateral patellar luxation in nine small breed dogs
The objective of this paper was to describe the clinical features, the management and the outcome of nine small breed dogs affected with lateral patella luxation referred during the period between January 2010 and Decem...
The effect of renal diet in association with enalapril or benazepril on proteinuria in dogs with proteinuric chronic kidney disease
Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin - converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have...
Ovine paratuberculosis: a confirmed case of Johne's disease in Libya
Paratuberculosis (Johne's disease) was suspected in a herd of approximately 033 sheep after weight loss and scouring had increased in adult animals despite repeated treatment with anthelmintics, antibiotics, multivitami...