THE EFFECT OF ROSELLA (HIBISCUS SABDARIFFA L) TREATMENT ON IL-10 AND IL-14 SECRETION ON DIMETHYLBENZ (A) ANTHRACENE (DMBA) INDUCED RAT
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The objective of this study was to determine the effect of ethanolic extract rosella calyx pretreatment on increasing secretion of IL-10 and IL-14 on SD rats treated with DMBA.Methods: Rats were treated with a dose of ethanol extract of roselle with 10, 50 and 100 mg / kg BW once daily for 21 days, then treated with DMBA 15mg / rat single dose. One week after DMBA treatment lymphatic organs of mice were taken and the expression of IL-10 and IL-14 were observed by immunohistochemistry using the appropriate antibodies. Further more it was observed using a microscope at 400x magnification.Result: The results showed that the obtained were analyzed using t-test to determine to what the effect of increased secretion of IL-10 and IL-14 between the control and treatment groups.Conclusion: Rosella calyx extract is potential to develop as immunomodulatory agent
Authors and Affiliations
Nurkhasanah .
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