The Effect of Short-term Intraperitoneal Injection of Fe2O4Zn Nanoparticle on Liver Enzymes and Tissue in Male Wistar Laboratory Rats
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 12
Abstract
The present study sought to examine the short-term effect of Fe2O4Zn nanoparticle on histological and enzymatic changes of liver in male Wistar laboratory rats. 24 male Wistar laboratory rats were divided into three groups. The control group included rats which received 0.5 ml of physiological saline. The second and third groups received 0.5 ml of Fe2O4Zn Nano fluid at concentration levels of 100 and 200 ppm for 7 consecutive days. The rats were phlebotomized on days 2, 7, and 14 following the treatment. Serum concentration levels of liver enzymes were measured. The livers were removed from the bodies on day 14. Serum glutamic oxaloacetic transaminase (SGOT), serume glutamic-pyruvic transaminase (SGPT), and alkaline phosphatase (ALP) levels saw a significant increase in both treatment groups compared to the control group on days 2, 7, and 14. Lactate dehydrogenase (LDH) levels, however, showed a reduction in the treatment groups compared to the control group which was not statistically significant. The histopathological analysis of liver tissues in treatment groups pointed to intrahepatocellular lipid accumulation, mild portal inflammation, hepatocyte inflammation, hyperemia, centrilobular, intravascular and portal red blood cell (RBC) aggregation, and centrilobular necrosis. Results from the second treatment group were more drastic than the first treatment group. Results demonstrate the histopathological effects of Fe2O4Zn on liver tissues and enzyme levels in the treatment groups compared to the control group
Authors and Affiliations
Somayeh Saadi| MSc, Department of Biology, Sanandaj Branch, Islamic Azad University,Sanandaj,Iran, CorrespondingEmail:Saadi.somayeh@yahoo.com, Zahra Hooshmandi| Department of Biology, Sanandaj Branch, Islamic Azad University,Sanandaj,Iran
Keywords
Related Articles
- EP ID EP12285
- DOI -
- Views 302
- Downloads 14
AN ETHNOBOTANICAL SURVEY OF MEDICINAL PLANTS USED BY TRADITIONAL HEALERS OF THADVAI, WARANGAL DISTRICT, ANDHRA PRADESH, INDIA
Since ancient times, plants have been used as medicine, foods, Agrochemicals and pharmaceuticals by large number of tribes, rural and urban people. India has more than 300 tribal communities. The tribal region of Andhr...
Association between sodium bicarbonate consumption and human health: A systematic review
Sodium bicarbonate or baking soda is a chemical compound dissolved in water which is widely used as an additive in foods and mineral water and as a medicine. In Iran, due to the introduction of harmful effects of this c...
Sphenoid Sinus Anatomical Relations and their Implications in Endoscopic Sinus Surgery
With advances in endoscopic sinus surgery (ESS), radiologist and otolaryngologists should have thorough knowledge of anatomy of paranasal sinus (PNS). Regarding this, sphenoid sinuses are the most variable among paranas...
Angiotensin I Converting Enzyme Gene Polymorphism in Type 2 Diabetes Mellitus with Nephropathy in Saudi Population
Background and aim: Diabetic Nephropathy (DN) is a major microvascular complication in Type 2 diabetes mellitus (T2DM). Several environmental and genetic factors play a pivotal role in the development and pathogenesis o...
Laboratory Tests Turnaround Time in Outpatient and Emergency Patients in Nigeria: Results of A Physician Survey on Point of Care Testing
Laboratory analytical turnaround time is a well-recognised indicator of how well a laboratory is performing and is sometimes regarded as the benchmark for laboratory performance. Methods: Total 104 doctors in public and...