The Effect of Smoking on Serum Nesfatin-1 Levels on Women Who are in Follicular Phase: A Pilot Study
Journal Title: Journal of Academic Research in Medicine - Year 2020, Vol 10, Issue 1
Abstract
Objective: Nesfatin-1, derived from NEFA/nucleobindin 2, is a hormone that suppresses food intake via melanocortin system in hypothalamus and has role on ovarian development. In this study, we aimed to determine the effect of smoking on serum nesfatin-1 levels on women who were in early follicular phase. Methods: This study included 32 female participants, as smokers (n=11) and non-smokers (n=21). Nesfatin-1, fasting blood glucose, low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol and tryglicerides, follicule stimulating hormone (FSH), luteinizing hormone (LH), antimüllerian hormone (AMH) and estradiol levels were measured from the blood samples in early follicular phase and they were compared. Results: 34,3% (n=11) of participants were smokers and according to the Fagerström Nicotine Dependence Scale whose nicotine dependence levels were >7 while 65.6% (n=21) were non-smokers. Serum nesfatin-1 levels in smokers were (81±0.1 pg/mL) found significantly lower than non-smokers (125±0.1 pg/mL) (p=0.007). No significant differences were found between these two groups about the levels of fasting blood glucose, LDL, HDL, total cholesterol, triglycerides, FSH, LH, AMH and estradiol. Conclusion: The levels of serum nesfatin-1 was found significantly lower in female smokers than the non-smokers in early follicular phase.
Authors and Affiliations
Durkadın Elif Yıldız , Zeynep Akçığ , Süleyman Salman , Elif Uçar , Sibel Tunç Karaman
Keywords
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