The effect of the products of ethanol metabolism on the liver – a review
Journal Title: Alkoholizm i Narkomania - Year 2018, Vol 31, Issue 3
Abstract
The consequences of consuming excessive amounts of alcoholic beverages are currently an important problem for many societies, not only in the context of treatment of alcohol dependence, but also the health effects of alcohol abuse. Long-term consumption of alcoholic beverages is associated with increased risk of hypertension, ischemic heart disease, also mouth and throat, stomach, liver or large intestine cancer. Due to almost 90% of consumed alcohol being broken down in the liver by oxidative pathways, this organ is particularly vulnerable to the effects of alcohol metabolism. The consequences of alcohol metabolism in the liver is the formation of byproducts, namely acetaldehyde and interaction between acetaldehyde and proteins, lipoproteins, DNA, also formation of reactive oxygen species and markers of inflammation, which can intensify immunological and inflammatory reactions and oxidative stress, thus contributing to the damage of hepatocytes, and development of alcoholic liver disease. There are three stages of alcoholic liver disease: alcoholic fatty liver disease, alcoholic hepatitis and alcoholic cirrhosis. The more advanced the disease, the worse the prognosis tends to be and the smaller the chance of recovery. Thus, alcoholic liver disease is a significant public health problem.
Authors and Affiliations
Aleksandra Kołota
Keywords
Related Articles
- EP ID EP539989
- DOI 10.5114/ain.2018.81664
- Views 92
- Downloads 0
The results of the two-year alcohol prevention program
The paper presents results of the second stage of a longitudinal outcome evaluation study aimed mostly at the assessment of preventive intervention effect stability over time. The two-year alcohol prevention program fo...
Przyczyny i strategie ograniczania przyjmowania środków psychoaktywnych przez pracownice agencji towarzyskich
Wprowadzenie Celem artykułu jest analiza motywów stojących za decyzją o ograniczeniu lub zaprzestaniu przyjmowania środków psychoaktywnych (przede wszystkim alkoholu) przez kobiety świadczące usługi seksualne w agencjac...
Sobering-up stations: Polish experiences
The author presents a history of sobering-up stations, which were founded as early as in the 1950s in Poland to protect drunken individuals from various risks and to offer them minimal medical care. Those persons “who ar...
Adaptacja amerykańskiego programu profilaktyki alkoholowej Fantastyczne Możliwości – znaczenie ewaluacji procesu i badań jakościowych
Przedmiotem artykułu jest prezentacja procesu adaptacji amerykańskiego programu profilaktyki alkoholowej dla uczniów 11–12-letnich i ich rodziców, w polskiej wersji nazwanego Fantastyczne Możliwości. Głównym celem progra...
Psychological roles of young adults growing up in alcoholic and non-alcoholic families measured by Family Roles Questionnaire
Introduction: This paper presents the process of developing the Family Roles Questionnaire (FRQ) research tool, which measures the psychological roles played by young adults in their families. Material and methods: Foll...