THE EFFECT OF TRIPEPTIDE T-34 ON NITRIC OXIDE SYSTEM AND LIPID PEROXIDATION PROCESSES IN STOMACH MUCOSA UNDER CONDITIONS OF WATER-RESTRAINT STRESS IN RATS
Journal Title: Праці Наукового товариства ім. Шевченка - Year 2017, Vol 49, Issue
Abstract
Stress was shown to involve multiple systems of human body and the search for safe and effective stress-protective compounds is an actual interdisciplinary task of the uptodate science. Literary data provides increasing evidence on the stress-protective features of the certain regulatory oligopeptides, in particular the tripeptide T-34 (H-Glu-Asp-Gly-OH), although its effect on mucous membranes of gastrointestinal tract is poorly elucidated. Aim of the study was to evaluate the effect of T-34 on nitric oxide system and lipid peroxidation processes in mucous membranes of the digestive organs under conditions of water immersion-restraint stress (WRS) in rats. The studies were conducted on white male rats, devided into 3 groups (n=6 per group): 1) control animals; 2) rats, exposed to WRS (5h); 3) rats, intragastrically pretreated with T-34 (10μg) 30 min before WRS exposure.
Authors and Affiliations
C. Nasadyuk, L. Biletska, A. Sklyarov
Keywords
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