The effect of vitamin D deficiency on serum sIL-2R, IL-6 and TNF-alpha levels in adults with Type 1 diabetes
Journal Title: Dicle Tıp Dergisi - Year 2015, Vol 42, Issue 4
Abstract
Objective: The aim of this study was to investigate the role of vitamin D deficiency in DMT1 pathogenesis by examining the effects of vitamin D levels on immune modulatory cytokines in patients with DMT1. Methods: Thirty adults with DMT1 from the endocrine clinic and 30 healthy controls were included in the study. Measurements for 25-hydroxyvitamin D (25OHD), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels were obtained from serum samples from each study participant. Measurements were compared between the control group and the patient group. Correlations between 25OHD levels and the levels of sIL-2R, IL-6, and TNF-α cytokines were investigated in patients with DMT1. Results: The mean 25OHD value for the DMT1 patients was significantly lower than for the control group (14.9±9.8 ng/ml versus 24.8±9.4 ng/ml, respectively; p<0.01). The mean sIL-2R and TNF-α scores for patients with DMT1 were significantly higher than for the control group (707.3 ± 265 U/mL versus 403.1 ± 128 U/mL, respectively; p<0.01; and 10.2±3.0 pg/mL versus 3.8 ± 1.6 pg/mL, respectively; p<0.01). There was no significant difference between the mean IL-6 scores of the DMT1 patients and the controls (3.7±1.5 pg/mL versus 4.6±1.3 pg/mL, respectively; p=0,202). Negative correlations with varying levels of significance were observed between 25OHD and sIL-2R, IL-6, and TNF-α cytokine levels in patients with DMT1. Conclusion: Vitamin D deficiency in DMT1 patients may contribute to disease pathogenesis by increasing sIL-2R, IL-6, and TNF-α cytokines. Key words: Diabetes mellitus type 1, vitamin D deficiency, soluble interleukin-2 receptor, interleukin-6, tumor necrosis factor-α
Authors and Affiliations
Mehmet Türken, Sedat Yılmaz , Leyla Çolpan, Belkis Aydınol, Alpaslan Tuzcu
Keywords
Related Articles
- EP ID EP164274
- DOI 10.5798/diclemedj.0921.2015.04.0604
- Views 113
- Downloads 0
Acil servise intihar girişimi ile başvuran yaşlı hastalarda mortaliteyi etkileyen sosyodemografik ve klinik faktörler
Giriş: Tüm dünyada olduğu gibi Türkiye’de de yaşlı nüfus oranı hızla artmaktadır. Buna paralel olarak ileri yaşta görülen psikiyatrik hastalıklar ve intihar eğilimi önem kazanmaktadır. Bu çalışmada, ilaç alımı ile intih...
Bir doğumevi gebe izlem polikliniğinde gestasyonel diyabetes mellitus sıklığı
Bu çalışmada rutin gebelik kontrolleri için gebe izlem polikliniğine başvuran hastalarda gestasyonel diabetes mellitus (GDM) tarama testleri ile GDM sıklığının hesaplanması ve yaşa göre sıklığının belirlenmesi amaçlandı....
Pulmoner aspergilloma nedeniyle akciğer rezeksiyonu ve latissimus dorsi kas flebi uygulaması: Olgu sunumu
Aspergilloma, aspergillus enfeksiyonunun en sık formu olup parankimal kaviteye saprofitik kolonizasyon ile görülür. Bu durum, başta tüberküloz olmak üzere bronşektazi ve sarkoidoz gibi çeşitli akciğer hastalıkları ile...
Factors affecting the success of weaning in patients with chronic obstructive pulmonary disease
Objectives: Weaning failure rate was higher in patients with chronic obstructive pulmonary disease (COPD) and many factors affect it. The aim of this study was to investigate the factors affecting the success of weaning...
The Factors Affecting Success of Pneumatic Retinopexy in Treatment of Retinal Detachment
Objective: To present the factors that influence the success rate of pneumatic retinopexy on rhegmatogenous retinal detachment treatment. Methods: Ninety eyes of 29 female and 61 male patient were included to the stud...