The effect of Vitamin D treatment on thyroid function and the levels of thyroid autoantibodies, TNF-α, IL-6, IL-1β in patients with autoimmune thyroiditis
Journal Title: Cumhuriyet Medical Journal - Year 2016, Vol 38, Issue 4
Abstract
Objective: To investigate the relationship between autoimmune thyroid disease and vitamin D treatment. Method: Fifty four (54) patients with both vitamin D deficiency and newly diagnosed euthyroid Hashimoto’s thyroiditis (HT) were recruited for this study. The patients were given intramuscular administration of cholecalciferol at a dose of 300,000 IU/month for 3 months. At the time of diagnoses and after the treatment of vitamin D, free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH), antithyroid peroxidase (anti-TPO), antithyroglobulin (anti-TG), 25 (OH) D3, parathormone (PTH), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) levels were measured in all patients; TNF-a, IL-6 and IL-1ß levels were measured in only 43 patients. Results: A statistically significant difference (p˂0.05) was observed between the pre and post treatment FT4, TSH, antiTPO, antiTG, PTH and ALP levels. After the treatment of vitamin D, a statistically significant increase was found in 25 (OH) D3 and FT4 levels, and a significant decrease was found in TSH, antiTPO, antiTG, PTH and ALP levels, whereas no significant difference was noted in FT3, Ca, P, TNF- a, IL-6 and IL-1ß levels. Further, levels of vitamin D were not correlated with FT3, FT4, TSH, antiTPO, antiTG, TNF-a, IL-6 and IL-1ß levels (p˃0.05). Conclusions: For patients with both vitamin D deficiency and newly diagnosed HT, treatment of vitamin D had a positive effect on the thyroid antigenicity and thyroid function.
Authors and Affiliations
Fettah Acıbucu, H. Sebila Dokmetas, Fatih Kılıclı, Cem Celik, Mustafa Aydemir
Keywords
Related Articles
- EP ID EP238254
- DOI 10.7197/cmj.v38i4.5000185086
- Views 114
- Downloads 0
A case who died due to the suicidal intake of aluminum phosphide
Although it is rarely seen in Turkey and developed countries, aluminum phosphide poisoning is an important heath problem because of its high mortality rate. Aluminum phosphate tablets in 3 g weight which are sold in the...
Work-related muscoskeletal symptoms and work impairment among workers in Turkish companies
Objective: Musculoskeletal disorders are major problems for the working population. The aims of study were to describe musculoskeletal symptoms (MSS) and work impairment among workers and to analyze the relationships bet...
Acute necrotizing encephalopathy as a H1N1 complication: A rare case
Abstract: Acute necrotizing encephalopathy of childhood (ANEC) is a rare type of encephalopathy seen generally in previously healthy children or infants of East Asian population. The pathology generally considered to be...
Impact of sociodemographic attributes on high-risk pregnancy
Objective: Identifying the association between sociodemographic data and laboratory parameters, and the complications occurring during the pregnancy monitoring. Method: This study reviewed 127 high-risk pregnant women (H...
Transverse mini skin incision for carpal tunnel release
Objective: Mini skin incision technique for median nerve release have become popular recently for the treatment of carpal tunnel syndrome. The main advantages of this technique are shorter recovery time and better cosmet...