The Effect on Gastric Emptying of Telaprevir-Based Triple Therapy for Chronic Hepatitis C Patients
Journal Title: Archives of Clinical Gastroenterology - Year 2015, Vol 1, Issue 1
Abstract
Aim: We evaluated food intake in telaprevir-based triple therapy (telaprevir, pegylated-interferon, and ribavirin) and its relation to Gastric Emptying (GE). Methods: 17 patients received telaprevir combined with pegylated interferon plus ribavirin. The GE study was carried out using the 13C-acetate breath test and GE time was expressed as the peak time of 13CO2 excretion (Tmax). Results: The average food intake was 1,851 ± 91, 1,338 ± 537 and 1,453 ± 537 kcal at 0, 1, and 2 weeks after the start of treatment, respectively, showing a significant decrease compared to that before treatment (p < 0.01 and p <0.05, paired t-test). The averages of Tmax values at 0, 1, and 2 weeks after the start of treatment were 48.4 ± 14.3 min, 56.9 ± 18.4 min and 58.0 ± 19.9 min, respectively. There was a significant difference between baseline and 1 week after the start of treatment (p<0.05, paired t-test). Food intake (kcal) showed a good correlation with the decrease of Tmax values (minutes) (Pearson’s correlation test, r = -0.49, p < 0.05). Conclusions: Telaprevir-based triple therapy caused reduced food intake and worsened GE.
Authors and Affiliations
Oyamada Arata, Arai Makoto, Matumura Tomoaki, Okimoto Kenichiro, Minemura Shoko, Saito Keiko, Maruoka Daisuke, Nakagawa Tomoo, Kanda Tatsuo, Katsuno Tatsuro, Yokosuka Osamu
Keywords
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- EP ID EP325146
- DOI 10.17352/2455-2283.000003
- Views 107
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