The Effectiveness of Ambon Banana Peel Extract (Musa sapientum) as Atherosclerosis Prevention through Inhibition of NF-κβ and Increased eNOS Expression in Atherogenic Rat Model
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 9
Abstract
Atherosclerosis is a disease in which plaque builds up inside the arteries. During the early phase, endothelial nitric oxide nitrate (eNOS) decrease and nuclear factor kappa beta (NF-κβ) increase. Ambon banana peel contains XJP-1 and flavonoid which has been shown to inhibit the translocation of NF-κβ and increase eNOS expression in endothelial cells. This study was designed to investigate the effectiveness of Ambon Banana peel as atherosclerosis preventive agent through the inhibition of NF-κB and increasing eNOS expression in atherogenic rats. This study was post-test only control group design for 14 days using 30 male Wistar rats, divided into 5 groups: negative control with normal diet, positive control with atherogenic diet, and three control groups with atherogenic diet + 200 mg/kg body weight/ day, 400 mg/kg body weight/day, and 800 mg/kg body weight/day extract dosage. On the 15th day, the rats were terminated, taken its abdominal aortic and analyzed using immunohistochemical method. Statistical analysis showed that the extract signifcantly decreases NF-κβ (p=0.00) and increase eNOS (p=0.00). Pearson correlation proves that higher dose can lower NF-κ NF-κβ activity and increase eNOS expression (p<0.05). Linear regression shows that the extract can 82.1% lower NF-κβ activity and increase eNOS expression for 95.2%. In conclusion, the extract of Ambon banana peel has been proven to be effective in preventing atherosclerosis.
Authors and Affiliations
Arlinda Silva Prameswari| Muhammadiyah University of Malang, Malang, Indonesia, Corresponding e-mail: arlindaoffcial@gmail.com, Kartika Puji Rahayu| Muhammadiyah University of Malang, Malang, Indonesia, Eria Nahrani Pranadita| Muhammadiyah University of Malang, Malang, Indonesia, Dyah Puspa Ardani | Muhammadiyah University of Malang, Malang, Indonesia, Wafyah Hasana| Muhammadiyah University of Malang, Malang, Indonesia
Keywords
Related Articles
- EP ID EP12453
- DOI -
- Views 323
- Downloads 13
ANESTHESIA FOR ELECTROCONVULSIVE THERAPY: A NOBLE APPROACH
Electroconvulsive therapy (ECT) has always proved to be an effective mode of therapy in the field of Psychiatry. Modified ECT is applied in the form of electrical stimulus to the central nervous system; it is associate...
Smartphones and professionalism: A cross-sectional study on interns and final-year medical students
The smartphone is a powerful tool that can be used to improve the health care system as long as certain checks and balances are implemented. It is commonly used by health care providers and medical students. A cross-sec...
Understanding Clinical Signifcance of GPI Anchored Proteins in Mammalian System: Special Emphasis on Genetic Disorders of GPI Anchor Biosynthesis Pathway
The mode of attaching the membrane protein with GPI anchor is known as GPI anchoring of protein and proteins thus formed are known as GPI anchored protein. GPI anchor is a glycolipid moiety which is synthesized in endop...
Bandage Contact Lens for Ultraviolet Light Photo keratitis
Subject: To compare usage of bandage contact lens (BCL) and eye patching on treatment of patient’s signs and symptoms with ultraviolet (UV) light exposure photo keratitis. Method: This prospective study included 32 pa...
COMPLETE DORSAL WALL DEFECT IN A DRY HUMAN SACRUM: A CASE REPORT
The human sacrum is a triangular bone formed by the fusion of five separate vertebras along with the intervertebral discs. Gross morphology of sacrum shows a concave ventral surface, a convex dorsal surface and a trian...