The Effectiveness of Ambon Banana Peel Extract (Musa sapientum) as Atherosclerosis Prevention through Inhibition of NF-κβ and Increased eNOS Expression in Atherogenic Rat Model
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 9
Abstract
Atherosclerosis is a disease in which plaque builds up inside the arteries. During the early phase, endothelial nitric oxide nitrate (eNOS) decrease and nuclear factor kappa beta (NF-κβ) increase. Ambon banana peel contains XJP-1 and flavonoid which has been shown to inhibit the translocation of NF-κβ and increase eNOS expression in endothelial cells. This study was designed to investigate the effectiveness of Ambon Banana peel as atherosclerosis preventive agent through the inhibition of NF-κB and increasing eNOS expression in atherogenic rats. This study was post-test only control group design for 14 days using 30 male Wistar rats, divided into 5 groups: negative control with normal diet, positive control with atherogenic diet, and three control groups with atherogenic diet + 200 mg/kg body weight/ day, 400 mg/kg body weight/day, and 800 mg/kg body weight/day extract dosage. On the 15th day, the rats were terminated, taken its abdominal aortic and analyzed using immunohistochemical method. Statistical analysis showed that the extract signifcantly decreases NF-κβ (p=0.00) and increase eNOS (p=0.00). Pearson correlation proves that higher dose can lower NF-κ NF-κβ activity and increase eNOS expression (p<0.05). Linear regression shows that the extract can 82.1% lower NF-κβ activity and increase eNOS expression for 95.2%. In conclusion, the extract of Ambon banana peel has been proven to be effective in preventing atherosclerosis.
Authors and Affiliations
Arlinda Silva Prameswari| Muhammadiyah University of Malang, Malang, Indonesia, Corresponding e-mail: arlindaoffcial@gmail.com, Kartika Puji Rahayu| Muhammadiyah University of Malang, Malang, Indonesia, Eria Nahrani Pranadita| Muhammadiyah University of Malang, Malang, Indonesia, Dyah Puspa Ardani | Muhammadiyah University of Malang, Malang, Indonesia, Wafyah Hasana| Muhammadiyah University of Malang, Malang, Indonesia
Keywords
Related Articles
- EP ID EP12453
- DOI -
- Views 331
- Downloads 13
Evaluating the efficacy of Regulated 12-Session Matrix Model in reducing susceptibility in methamphetamine-dependent individuals
Methamphetamine (ab)use have gained popularity among youth and is increasingly become a part of mainstream culture. Methamphetamine(ab)use is dangerous because of its wide range adverse outcomes and hazardous sustainin...
The Neuroprotective Effects of Alcoholic Extract of Levisticum Officinale on Alpha Motoneurons’ Degeneration After Sciatic Nerve Compression in Male Rats
As peripheral neurons are injured, several inflammatory factors will be released from the fiber of the injured nervous leading to morphological and biochemical changes in the injured point. This changes ultimately resul...
Peak Exercise Response to Vertical Climbing in Chronic Obstructive Pulmonary Disease Patients
Background: Stair climbing is an integral component of daily living, which is limited in COPD. To date, stair climbing is used for prediction of VO2Max, pulmonary function, and postoperative complications. The study is...
COMPARATIVE STUDY OF FLUTICASONE PROPIONATE WITH BUDESONIDE AND BECLOMETHASONE DIPROPIONATE IN MILD PERSISTENT BRONCHIAL ASTHMA
Objective: To compare the efficacy and adverse effects of fluticasone propionate with that of budesonide and beclomethasone dipropionate in mild persistent cases of bronchial asthma. Methods: This was an open label, ra...
Complications During and One Month after Surgery in the Patients Who Underwent Thoracoscopic Surgery
Thoracoscopy is a new method in surgery whose role is expanding in a wide range of diagnosis and treatment of chest disorder. Thoracoscopy has many diagnostic and therapeutic benefits, and knowing about the complication...