The Effectiveness of Ondansetron versus Tramadol as Pretreatment in Alleviating Propofol Injection Pain: A Comparative Study
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 9
Abstract
Introduction: Propofol is widely used for induction of anesthesia, although the pain during its injection remains a concern for all anesthesiologists. A number of techniques have been adopted to minimize propofol-induced pain. Various 5-hydroxytryptamine- 3 antagonists have shown to reduce propofol-induced pain. Hence, this placebo-controlled study was conducted to compare the efficacy of ondansetron, ramosetron, and lignocaine in terms of attenuation of propofol-induced pain during induction of anesthesia. Aim of the Study: To assess the effectiveness of ondansetron and tramadol as pre-treatment in alleviating propofol injection pain. Materials and Methods: 36 patients were randomly allocated into two groups. Group 1 who received up to 2 mL pretreatment with 50 mg tramadol with 1 ml NS while group 2 cases who received 2 mL pretreatment 4 mg ondansetron. The drug is injected into the largest vein on the dorsum of the hand by means of a 20 gauge cannula and the tourniquet being closed to the arm above the cannula and inflated upto 70 mmHg. The tourniquet is deflated after 20 seconds and propofol 2mg/kg injected over 10 seconds and assessment for pain was made. Results: Tramadol and ondansetron both reduced the incidence and severity of propofol injection pain but pain reduction with ondansetron was significant compared to tramadol (p=0.0402). Significantly 14 patients in the ondansetron group felt no pain when compared to only 8 patients in the tramadol group. Conclusion: In addition,ondansetron had the additional benefit as it controlled postoperative nausea and vomiting.
Authors and Affiliations
Mu. Raajaram
Keywords
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- EP ID EP539172
- DOI 10.21088/ijaa.2349.8471.5918.14
- Views 100
- Downloads 0
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