The Effects of 6% Hydroxyethyl Starch on Ischemia - Reperfusion Injury in Total Knee Arthroplasty with Tourniquet Application
Journal Title: International Journal of Anesthesiology & Research (IJAR) - Year 2017, Vol 5, Issue 5
Abstract
We investigated the effects of 6% hydroxyethyl starch (HES) infusion on ischemia-reperfusion injury in total knee arthroplasty using pneumatic tourniquet application. Before induction of spinal anesthesia and 15 minute after tourniquet release, we examined plasma malondialdehyde (MDA) levels to determine the degree of lipid peroxidation after ischemia-reperfusion. Sixty patients of American Society of Anesthesiologists physical status I to II having unilateral total knee arthroplasty with tourniquet randomly assigned into 2 groups. Group NS received normal saline 10ml/kg and group HES received hydroxyethyl starch solution 10ml/kg respectively during spinal anesthesia. Blood samples for the analysis of plasma MDA were drawn twice at before induction and 15 minute after tourniquet release. In group NS, plasma MDA level was not different between before and after tourniquet release (2.20 ± 0.36 nmol/ml, 2.26 ± 0.43nmol/ml, p=0.37). In group HES, plasma MDA level was significantly increased before and after tourniquet (1.84 ± 0.43 nmol/ml, 1.96 nmol/ml, p=0.026). Hydroxyethyl starch solution have no preventive effects on lipid peroxidation after ischemic-reperfusion oxidative stress
Authors and Affiliations
Jae Ho Lee
Keywords
Related Articles
- EP ID EP279656
- DOI 10.19070/2332-2780-1700091
- Views 94
- Downloads 0
Does the Administration of Preoperative Midazolam Assist in Maintaining Blood Glucose Norms in the Non - Diabetic Patient during the Perioperative Period?
Introduction: Surgery induces stress response, which can cause elevated blood glucose level. In addition to tissue injury and inflammation, anxiety can contribute to the stress response. We measured the effect of preoper...
Ossification of the Posterior Longitudinal Ligament: A Case Report of Difficult Intubation in a Resource Limited Setting
Ossification of the posterior longitudinal ligament (OPLL) is a rare and often unrecognized cause of difficult intubation that is most commonly found in elderly Asian males. This case report will describe the airway mana...
Serotonin Syndrome Following Methylene Blue Administration for Vasoplegic Syndrome in Heart and Lung Transplantation – A Case Series
Serotonin syndrome is a potentially life threatening adverse drug reaction caused by excessive activation of postsynaptic serotonin receptors in the central nervous system (CNS). It is typically associated with the simul...
Asystole During Airway Manipulation In Neurosurgical Patient: Causes And Management
Hemodynamic disturbances in neurosurgical patients may be attributed by various neurogenic causes mainly raised intracranial pressure (ICP); however, cardiovascular perturbations during airway management in such patients...
Comparison of Arndt-Endobronchial Blocker Set (AEBS) with Double-Lumens Endobronchial Tube (DLT) in One Lung Ventilation in Thoracic Surgery
One lung ventilation (OLV) for thoracic surgery is usually achieved with a double-lumen endobronchial tube (DLT) or bronchial blocker. However, nasal intubation is not easy in some cases. Here, we investigate the compari...