The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer
Journal Title: International Journal of Applied Exercise Physiology - Year 2016, Vol 5, Issue 4
Abstract
Background: In the present study, the effects of endurance training and chronic administration of Gallic acid (GA) on hippocampal level of brain-derived neurotrophic factor (BDNF) and tumor necrosis factor alpha (TNF-α) in trimethyltin (TMT)-induced hippocampal degeneration as a model of Alzheimer’s disease were investigated. Methods: 70 male Sprague-Dawley rats were selected and randomly assigned to 7 groups: 1.control, 2.TMT, 3.TMT+GA50, 4.TMT+GA100, 5.TMT+Ex, 6.TMT+Ex+GA50, 7.TMT+Ex+GA100. For induction of Alzheimer's disease, the rats in groups 2-7 were injected with single dose of TMT (8 mg/kg), intra-peritonealy (i.p.). Rats in the groups 5, 6 and 7 carried out an 8-week exercise program on a motorized treadmill (15-20 m/min, 0% inclination for 15- 30 min/day, 5 days/week). In addition, the groups 3 and 6 were treated by 50 mg /kg and groups 4 and 7 are administered 100 mg/ kg of Gallic acid for 2 weeks. Then, the hippocampal level of BDNF and TNF-α was performed for all groups by Elisa. Results: The findings of present study showed that the hippocampal level of BDNF in all test groups are significantly higher than TMT group (p≤0.05) and the hippocampal level of TNF-a in all test groups is significantly less than the TMT group (p≤0.05). Conclusion: Endurance exercises training, chronic administration of GA and co-treatment with training and GA consumption specially, having sufficient neurotrophic and immune modulator effects in male rats with Alzheimer.
Authors and Affiliations
Mohammad Amin Edalatmanesh, Yoones Baziyar, Seyed Ali Hosseini, Abdossaleh Zar
Keywords
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