The effects of ethanolic extract of green algae (ulva lactuca l.) on blood cholesterol levels in male rats induced by a high fat diet
Journal Title: Jurnal Kedokteran dan Kesehatan Indonesia - Year 2016, Vol 7, Issue 5
Abstract
Background : Nowadays, cardiovascular disease is increasing in number each year. It is triggered by high cholesterol diet consumed by urban people. Green algae (Ulva lactuca L.) contains phytomelatonin levels that can ease cholesterol. Objective : To know about the effect of giving green algae ethanolic extract in male strain Wistar mice’s cholesterol level. Methods : This research involved 36 male strain Wistar mice divided to six groups. Negative control injected with 2 ml/200 gBW lard, positive control injected with 0,18 mg/200 gBW simvastatin and lard, group III, V, V each given lard and injected with ethanolic extract of green algae at a dose of 50 mg/kgBW, 100 mg/kgBW and 200 mg/kgBW respectively, and normal control given AD 2 dietary treatment. Each group was given the same treatment peroral in 56 days and the blood was taken every 14 days through sinus orbitalis. The blood cholesterol level was analyzed by using enzymatic CHOD-PAP method. Data obtained were statistically examined using Two way ANOVA , Kolmogorov Smirnov, Levene’s method and LSD with confidence level at 95%. Results : The blood cholesterol level were not significanly different between the negative and normal control. The result of cholesterol level for 14, 28, and 42 days for all group did not increase compared to negative control, but cholesterol level in group with 200 mg/kgBW dose extract indicated significant difference with negative control for 56 day. Conclusion : Giving ethanolic extract of green algae for 56 days decreased blood cholesterol level in male rats.
Authors and Affiliations
Wahyu Widyaningsih
Keywords
Related Articles
- EP ID EP253697
- DOI 10.20885/JKKI.Vol7.Iss5.art3
- Views 105
- Downloads 0
The roles of prayers in Islam for treatment (healing); potencies and problems
No Abstract
Peripartum Cardiomyopathy (PPCM) : Case Report and Review of Literatures
Introduction: Peripartum cardiomyopathy (PPCM) is a disease characterized by an enlargement of the heart muscle wall. The disease occurs in the last month of pregnancy up to 5 months postpartum, with no previous history...
Profile of medication variations and dose adjustment to diabetes mellitus patients’ response in PKU Muhammadiyah hospital and Panti Rapih hospital period October–December 2014
Background: Diabetes mellitus patients may have a different response to similar medication. Therefore, individualized treatment and monitoring of the therapy is needed to ensure the patients’ response. Alternative medica...
Risk factors of stroke survivors' quality of life
Background : Stroke can lead into long-term disabilities which may affect stroke survivors' quality of life (QOL). The importance of stroke survivors' QOL is still getting little attention. Objective : To know stroke su...
Characteristics of children with secondhand smoking
Background: Passive smoking has been known to be associated with the risks of several diseases. Children are a group vulnerable to becoming passive smokers through adjacent adult smokers. Objective: To describe the chara...