The Effects of Highly Active Antiretroviral Therapy on the Activities of Some Liver Enzymes and the Concentrations of Protein and Albumin in HIV Positive Patients in Nsukka South East Nigeria
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 7
Abstract
Some biological changes are observed during human immuno deficiency virus (HIV) infection. Once cluster of differentiation 4 (CD4+) count decreased to 500 cells/mm3 (highly active antiretroviral therapy) (HAART) is initiated. This work tried to elucidate the effect of HAART on some of the biochemical changes caused by HIV infection. 63 subjects comprising, 20 apparently healthy control subjects and 43 HIV positive subjects ready to be placed on HAART (these subjects attended HIV clinic in Bishop Shanahan Hospital Nsukka) were recruited for the study. A known volume of blood, 10ml was collected from each subject through venepuncture prior to the initiation of HAART (basal sample) then 4 and 8 months into the administration of HAART. The activities and concentrations of the following biochemical parameters: Aspartate amino transferase (AST), Alanine, amino transferase (ALT), total protein and albumin, were determined. CD4+ count was also determined at each presentation. The results showed that CD4+ count increased significantly from baseline to 8 months into treatment (p < 0.05), ALT and AST increased from baseline to 4 months into treatment, but decreased by the 8th month, (ALT: p < 0.05) (AST: p > 0.05). Total protein and albumin increased significantly from baseline to 8 months into treatment (p < 0.05). Even though the studied parameters improved because of treatment they were still significantly different from the observations made for the healthy control subjects (p < 0.05). Hence treatment with HAART amounted to a positive prognosis for HIV/AIDS infection as it concerns liver enzymes and plasma protein and albumin.
Authors and Affiliations
Aniagolu Miriam O
Keywords
Related Articles
- EP ID EP370370
- DOI -
- Views 47
- Downloads 0
A Rare Case of Poland’s Syndrome
Poland’s syndrome is a rare congenital anomaly consisting of a unilateral absence of the pectoralis major, hand anomaly and occasionally associated other malformation. Many structural and functional abnormalities have be...
Correlation of Functional Capacity and Disease Severity Indices with Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
Background: Chronic Obstructive Pulmonary Disease (COPD) reduces exercise capacity which in turn restricts patient’s ability to carry out daily activities and affects Quality Of Life (QOL). Six minute walk test is a simp...
Klippel-Feil Syndrome: A Case Report
Klippel-Feil Syndrome (KFS) is defined as a congenital fusion of two or more cervical vertebrae. The most common signs are short neck, low hairline at the back of the head, and restricted mobility of neck. I report on a...
Evaluation of the Human Enamel Surface Morphology after Tooth Bleaching Followed By Remineralizing Agents
Background: Over the last two decades there was dramatic growth and impact of tooth whitening worldwide which raised patients’ awareness of the appearance of their smile. The exposure of tooth surface to various dental b...
Awareness Regarding the Care of Patients with HIV/AIDS among the Nurses Working at BPKIHS, Nepal
Background: Nurses play a critical role in caring the HIV positive patient. A knowledge deficit about HIV/AIDS nursing care could logically affect outcomes of care for these patients. Negative attitudes and behaviors rel...