The Effects of Immunomodulatory Molecule- Lipoxin A4- on The Physiology of Cystic Fibrosis Human Bronchial Epithelium
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 5
Abstract
<strong>ABSTRACT</strong> Cystic fibrosis (CF) is a disease characterised by the depletion of Airway Surface Liquid (ASL) height. Lipoxin A<sub>4</sub> was found to be effective in restoring ASL back to normal by acting on ENaC. The signalling mechanisms involved in lipoxin effect were investigated by testing the action of a calcium chelator (Bapta-AM) and Protein kinase C inhibitor (GF 109203X) on NuLi-1 and CuFi-1 cells. Drug’s efficacy was monitored by conducting Ussing chamber experiments and confocal microscopy. Results showed that calcium has a major contribution to the lipoxin A<sub>4</sub> effects while PKC has a limited role. However, our data might lack accuracy due to shortage of time to conduct more experiments. <strong> </strong>
Authors and Affiliations
Eman Helal
Keywords
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