The Effects of Iron Oxide Nanoparticles Administration on Depression Symptoms Induced by LPS in Male Wistar Rats
Journal Title: Basic and Clinical Neuroscience - Year 2015, Vol 9, Issue 3
Abstract
Introduction: Depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for one to several weeks. Several studies have shown that iron nanoparticles have neuroprotective and anti-inflammatory effects. This study aimed to evaluate anti-depressive effect of iron nanoparticles in male rats. Methods: Depression was induced by Lipopolysaccharide (LPS) adminstration. Rats were randomly assigned into six groups (10 in each group): 1) control (sterile saline solution; 200 µL, IP); 2) LPS (LPS;100 μg/kg, IP); 3) Low dose Iron Nanoparticle (LINP) (1 mg/kg, IP); 4) High dose Iron Nanoparticle (HINP), 5 mg/kg IP); 5) LPS/LINP (LPS; 100μg/kg IP+INP 1 mg/kg IP); and 6) LPS/HINP (LPS; 100 μg/kg IP+INP 5 mg/kg IP). All injections were performed every other day. To assess the effect of iron nanoparticles on depression symptoms, rats were subjected to two behavioral tests: Forced Swim Test (FST) and Open Field Test (OFT). Results: Iron nanoparticles treatment in 1 mg/kg and 5 mg/kg doses groups significantly improved depression symptoms when assessed by OFT and FST. In OFT, the number of line crossings, entrance to central square, rearing and duration of attending in central square increased after iron nanoparticles adminstration in depressed rats. Iron nanoparticles adminstration reduced immobility time confirmed by FST and OFT. Also, iron nanoparticles adminstration significantly increased duration of swimming in FST depressed rats. Conclusion: Our results for the first time showed potential advantageous effect of iron nanoparticles administration in attenuating depression symptoms, which was possibly mediated by modulation of neurotransmitters and anti-inflammatory effects of iron nanoparticles.
Authors and Affiliations
Fatemeh Saeidienik, Mohammad Reza Shahraki, Hamed Fanaei, Fereshteh Badini
Keywords
Related Articles
- EP ID EP455089
- DOI 10.29252/nirp.bcn.9.3.209
- Views 57
- Downloads 0
Environmental Enrichment Attenuates Morphine-Induced Conditioned Place Preference and Locomotor Sensitization in Maternally Separated Rat Pups
Introduction: This study investigated the effect of the environmental enrichment during adolescence on morphine-induced Conditioned Place Preference (CPP) and locomotor sensitization in maternally separated male and fema...
Predicting the Risk of Hearing Impairment Following the Cervical Spine Diseases by Measuring the Cervical Range of Movements: A Pilot Study
Introduction: Cervical spine abnormalities can affect the ear vessels and or nerves with different mechanisms. Ear dysfunctions following cervical spine injuries can be manifested as hearing loss, vertigo, or tinnitus. U...
Sleep Architecture in Patients With Primary Snoring and Obstructive Sleep Apnea
Introduction: This study aimed to investigate sleep architecture in patients with primary snoring and obstructive sleep apnea. Methods: In this study, we analyzed polysomnographic data of 391 clients who referred to Slee...
Stereological Method for Assessing the Effect of Vitamin C Administration on the Reduction of Acrylamide-induced Neurotoxicity
Introduction: Acrylamide (ACR) consumption is increasing all over the world. There are some evidence on the literature about its neurotoxic effect on mature animals, but the effects of ACR on postnatal development have b...
The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats
Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current s...