The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study
Journal Title: Meandros Medical and Dental Journal - Year 2019, Vol 20, Issue 1
Abstract
Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for post-operative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats’ bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats’ bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to group 1, and ibuprofen to group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p<0.05) in group 2, and the relaxation response reached the baseline tonus in this group. Conclusion: Intraoperative analgesia is very important in preventing post-operative complications and ensuring patient comfort. In general, opioids and concomitant nonsteroidal anti-inflammatory or paracetamol group drugs are preferred intraoperatively for post-operative analgesia. In our study, although there was no effect of paracetamol on rat bronchi with supramaximal tonus, ibuprofen showed an unexpected significant relaxation response. In conclusion, ibuprofen may be preferred much more the than paracetamol in patients with high risk of clinical bronchospasm.
Authors and Affiliations
Ali Onur Erdem, Sezen Özkısacık, Mesut Yazıcı, Kamil Varlık Erel
Keywords
Related Articles
- EP ID EP48955
- DOI 10.4274/meandros.galenos.2018.72692
- Views 314
- Downloads 0
Evaluation of the Effect of Different Curing Units and Exposure Times on Pulp Chamber Temperature Using Simulated Pulpal Microcirculation
Objective: To compare the elevations in physiological pulp chamber temperature and blood microcirculation during light curing using four different light sources at two different exposure times. Materials and Methods: Th...
Evaluation of Pharyngeal Airway Volume in Individuals with Different Skeletal Patterns
Objective: This retrospective study aimed to evaluate and compare the airway shape and volume using cone-beam computed tomography (CBCT), which allows three-dimensional examination of the airway in individuals with diffe...
A Reason of Facial Diplegia: Guillain- Barré Syndrome
Guillain-Barré syndrome (GBS), an acute demyelinating inflammatory poliradiculopathy, is characterised by rapidly progressive, symmetrical, ascending weakness and areflexia. The disease usually occurs after 1-3 weeks of...
Anaphylaxis After the First Dose of Lansoprazole: A Case Report
Drug-induced anaphylaxis is a life-threatening condition that is rapid in onset and defined as a serious allergic or hypersensitivity reaction. Proton pump inhibitors are widely used for the treatment of acid-related dis...
Investigating the Effect of Rosuvastatin, Paracetamol and Co-administration of Rosuvastatin and Paracetamol on Ocular Tissue
Objective: Statins and Paracetamol are two drugs that have a high prescription rate all over the world. Possible side effects can easily be augmented because they use the same cytochrome oxidase enzymes in liver. This st...