The Effects of Paracetamol and Ibuprofen on Smooth Muscle Response of the Bronchospasm: An In Vitro Study
Journal Title: Meandros Medical and Dental Journal - Year 2019, Vol 20, Issue 1
Abstract
Objective: Bronchospasm is a very important complication that can be encountered during the post-operative and intraoperative periods. This complication may be caused by surgery, anesthesia, or patient-related issues. Many analgesics are preferred during the intraoperative period for post-operative analgesia. In this study, we aimed to investigate the effects of ibuprofen and paracetamol on rat bronchus with supramaximal tonus as a model of bronchospasm under in vitro conditions. Materials and Methods: Totally, 20 male rats were used in our study. After the ketamine anesthesia, the left main bronchus of each rat was removed and suspended in the organ bath in Krebs solution. Four rat bronchi were excluded because of not demonstrating viability with atropine and acetylcholine. After demonstrating the viability of the rats’ bronchi (n=16), acetylcholine was applied to produce supramaximal contraction. The rats’ bronchi with supramaximal contraction were randomly divided into two groups. Paracetamol was applied to group 1, and ibuprofen to group 2. The contraction responses of each group were recorded and compared statistically. Results: While a statistical significance was not detected regarding the supramaximal contraction in group 1 with a mean of 0.18±0.07% (p>0.05), tonus was reduced to 6.79±0.28% (p<0.05) in group 2, and the relaxation response reached the baseline tonus in this group. Conclusion: Intraoperative analgesia is very important in preventing post-operative complications and ensuring patient comfort. In general, opioids and concomitant nonsteroidal anti-inflammatory or paracetamol group drugs are preferred intraoperatively for post-operative analgesia. In our study, although there was no effect of paracetamol on rat bronchi with supramaximal tonus, ibuprofen showed an unexpected significant relaxation response. In conclusion, ibuprofen may be preferred much more the than paracetamol in patients with high risk of clinical bronchospasm.
Authors and Affiliations
Ali Onur Erdem, Sezen Özkısacık, Mesut Yazıcı, Kamil Varlık Erel
Keywords
Related Articles
- EP ID EP551051
- DOI 10.4274/meandros.galenos.2018.72692
- Views 140
- Downloads 0
Investigation of Oral Candida Albicans Colonization in Patients Treated with Rapid Maxillary Expansion
Objective: The purpose of this study was to investigate Candida albicans colonies in the oral microflora of patients treated with rapid maxillary expansion (RME). Materials and Methods: Totally 54 male and female subject...
Selexipag: A New Treatment Agent for Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a rare disease which is characterized by the progressive increase of pulmonary arterial pressure. PAH can lead to right cardiac insufficiency and death. Conventional and other tre...
Loneliness and Social Isolation among Eldely People
Social isolation is defined as the process of people losing their contacts with other social resources or their willingness to participate. Social isolation is a grave and widespread problem among seniors in society caus...
Vitamin D Level and Infertility
Infertility is one of the major health problems of our time. In fact, infertility is caused by many factors. Among these factors the effect of vitamin D levels of infertility are overlooked. The prevalence of vitamin D d...
Peroneal Nerve Palsy due to Synovial Cyst of Proximal Tibiofibular Joint
Synovial cysts are benign soft-tissue tumors that arise from synovial joints or tendon sheaths. Synovial cyst of proximal tibiofibular joint is a very rare condition, which is included in non-traumatic causes of peroneal...