The Effects of Pulmonary Arterial Hypertension on the Heart Work Dynamics: Gender Differences
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
Aim: The aim of this paper was to find out possible changes of heart work dynamics induced by pulmonary artery hypertension in male and female rats. Materials and methods: Experiments were performed on the Wistar rats of both genders. Pulmonary hypertension (PAH) was induced by i.p. injection of monocrotaline (60 mg/kg B.W.) on day 0 to 21 days observational period. After that, animal was sacrificed, hearts removed and papillary muscles from right ventricle isolated. Velocity of heart contraction (+dF/dt) and relaxation (-dF/dt) were measured. Additionally, pathomorphologic analysis of lung blood vessels has been carried out. Result: PAH induced significant reduction of velocity of contraction (+dF/dt ) and relaxation (-dF/dt) in both male (+dF/dt: 3,41 ± 0,33 mN/s vs. 2,53 ± 0,31 mN/s, n=6, p<0,05; -dF/dt: 1,96 mN/s ± 0,26 vs. 1,2 ± 0,17 mN/s, n=6, p<0,01) and female rats ( +dF/ dt: 3,09 ± 0,35 mN/s vs. 1,86 ± 0,22 mN/s, n=6, p<0,05; -dF/dt: 1,63± 0,11 mN/s vs. 0,89 ± 0,097 mN/s, n=6, p<0,01).Adrenergic responsivness to noradrenaline with reference to both parameters of heart dynamics (+dF/dt and =dF/dt) was increased significantly only in male rats. Additionally, PAH induced thickness of the lung blood vessels in both genders. Conclusion: PAH reduced dynamic of heart work (especially relaxation velocity) in both male and female rats, but significantly increased sensitivity to adrenergic stimulation in male rats only.
Authors and Affiliations
Ivan Kocic, Katarzyna Sztormowska Achranowicz
Keywords
Related Articles
- EP ID EP622356
- DOI 10.26717/BJSTR.2019.19.003334
- Views 149
- Downloads 0
Study of Chondrosarcoma in Northwest Region of Libya
Chondrosarcoma (CS) is a relatively rare malignant tumor of chondroblasts with pure hyaline cartilage differentiation. The neo-plastic cells do not synthesize osteoid, but areas of calcification, ossification and myxoid...
Qualitative Properties and Antibacterial Activity of Essential Oil obtained from Citrus sinensis Peel on Three Selected Bacteria
Medicinal plants are essential curative agents for different types of ailments. Citrus sinensis contains important micronutrients such as vitamin C and E, carotenoids and flavonoids, essential for maintenance of human he...
Evolution and Epidemiology of Antimicrobial Resistance: Staphylococcus aureus
Staphylococcus aureus is a potentially pathogenic bacterium that causes a wide range of diseases. These are causing different infections and resistance mechanism due to of its wide virulence factors. The increase in the...
A Cross-Sectional Study of the Attitudes and Perceptions towards BiologicallyBased Therapies in the United Arab Emirates
Biologically-Based Therapies (BBTs) are a subset of Complementary and Alternative Medicine (CAM) Therapies that fall into four main categories; diet therapy, herbal therapy, orthomolecular therapy and chelation therapy....
Imatinib Induced Delayed and Refractory Generalized Fluid Retention: A Case Report and Review of Literature
Imatinib is a tyrosine kinase inhibitor used mainly for ABL-BCR positive CML. Development of fluid retention(FR) following imatinib therapy is the most common side effect. However, sever FR as generalized anasarca, pleur...