The Effects of Pulmonary Arterial Hypertension on the Heart Work Dynamics: Gender Differences
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
Aim: The aim of this paper was to find out possible changes of heart work dynamics induced by pulmonary artery hypertension in male and female rats. Materials and methods: Experiments were performed on the Wistar rats of both genders. Pulmonary hypertension (PAH) was induced by i.p. injection of monocrotaline (60 mg/kg B.W.) on day 0 to 21 days observational period. After that, animal was sacrificed, hearts removed and papillary muscles from right ventricle isolated. Velocity of heart contraction (+dF/dt) and relaxation (-dF/dt) were measured. Additionally, pathomorphologic analysis of lung blood vessels has been carried out. Result: PAH induced significant reduction of velocity of contraction (+dF/dt ) and relaxation (-dF/dt) in both male (+dF/dt: 3,41 ± 0,33 mN/s vs. 2,53 ± 0,31 mN/s, n=6, p<0,05; -dF/dt: 1,96 mN/s ± 0,26 vs. 1,2 ± 0,17 mN/s, n=6, p<0,01) and female rats ( +dF/ dt: 3,09 ± 0,35 mN/s vs. 1,86 ± 0,22 mN/s, n=6, p<0,05; -dF/dt: 1,63± 0,11 mN/s vs. 0,89 ± 0,097 mN/s, n=6, p<0,01).Adrenergic responsivness to noradrenaline with reference to both parameters of heart dynamics (+dF/dt and =dF/dt) was increased significantly only in male rats. Additionally, PAH induced thickness of the lung blood vessels in both genders. Conclusion: PAH reduced dynamic of heart work (especially relaxation velocity) in both male and female rats, but significantly increased sensitivity to adrenergic stimulation in male rats only.
Authors and Affiliations
Ivan Kocic, Katarzyna Sztormowska Achranowicz
Keywords
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- EP ID EP622356
- DOI 10.26717/BJSTR.2019.19.003334
- Views 166
- Downloads 0
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