The Effects of Short-term Repeated Oral Administration of Potassium Cyanide on Some Haematological Indices and Internal Organs Morphology of Rabbits
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 8, Issue 4
Abstract
This study investigated the effects of short-term repeated oral administration of sub-toxic dose of potassium cyanide on the haematological indices and the structure of the thyroid, liver, adrenal, and spleen of rabbits. A total of 16 rabbits, weighing 1.2±0.2 kg were randomly divided into two groups. Group 1 was the control, and the animals were treated with 10 mL/kg body weight of distilled water per os. Group 2 was treated with 0.3 mg/kg potassium cyanide (KCN) in distilled water per os. Results revealed atrophy and distended thyroid follicles with flattened epithelial cells only in the cyanide treated group. The liver revealed severe periportal lymphocytic infiltration only in the cyanide treated animals, coupled with focal areas of hepatocellular coagulative necrosis, and cholangitis. The spleen revealed mild congestion of the red pulp in both treated and control groups, while hemosiderosis was seen only in the cyanide treated group. There was no visible lesion in the adrenal gland. The values of parameters evaluated in the KCN- treated animals were as follows: Packed Cell Volume (PCV) (33.25±2.4%), Red blood Cell Count (RBC) (6.93±0.7 x 106/μL), TWBC (Total White Blood cell Count) (9.4±1.0 x103/μL), Haemoglobin Concentration (HC) (14.7±1.9 g/dL), Aspartate Transaminase (AST) (29.8±5.7 IU/mL), Alanine amino transaminase (ALT) (12.8±1.8 IU/mL) and Alkaline Phosphatase (ALP) (48.0±5.7 IU/mL). Those of controls were PCV (31.0±0.94%), RBC (5.45±O.3 x106/μL), TWBC (6.8±0.43 x103/μL), HC (11.07±0.94 g/dL), AST (16.33±0.3 IU/mL), ALT (8.33±1.0 IU/mL), ALP (23.7±2.8 IU/mL). There was no significant difference (p<0.05) between the haematological indices of the treated and the control group. AST and ALP of the treated group was significantly higher (p<0.05) than that of the control.
Authors and Affiliations
Igbokwe Casmir Onwuaso, Omoja Valentine Uneojo, Ubachukwu Chidiebere
Keywords
Related Articles
- EP ID EP353457
- DOI 10.9734/ARRB/2015/21828
- Views 110
- Downloads 0
The Mechanism of Action of Rhizobacteria Enterobacter nimipressuralis 32-3 on the Mineral Nutrition and Productivity of Soybean
The aim of the research was to study the mechanism of action of soil rhizobacteria E. nimipressuralis 32-3 on the elements of mineral nutrition of soybean (сontent of N and Р2О5 in shoot, productivity of plants), quali...
In vitro Regeneration of Banana and Assessment of Genetic Fidelity in the Regenerated Plantlets through RAPD
Amrit Sagar belonging to banana (Musa acuminata) genome group AAA is popularly grown in North Eastern part of India for its high yield and natural disease resistance potential. The explants were established initially on...
Ecology and Protein Composition of Polypedates leucomystax (Gravenhorst, 1829) (Anura: Rhacophoridae) Foam Nests from Peninsular Malaysia
The four-lined tree frog, Polypedates leucomystax, spawns its eggs in a moist structure called a foam nest. Four foam nests constructed by this species were collected from the Sungai Sedim Recreational Forest, Kedah, Pen...
Review: Current Diagnosis, Treatment and Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Polyradiculoneuropathy is a complex neuromuscular condition which has its etiology either acquired or inherited form. There are a number of neuromuscular conditions that can affect combinations of nerve root, junction, a...
Bacteriocins Contributing in Rhizospheric Competition among Fluorescent Pseudomonads
Aims: To examine the production of bacteriocins through the study of a group of rhizospheric Pseudomonas isolates already known to produce metabolites that are antagonistic to fungi. Methodology: Fourteen rhizospheric st...