THE EFFECTS OF THE H1-RECEPTOR BLOCKERS ON ADENOSINE DEAMINASE, XHANTHINE OXIDASE AND TRACE ELEMENTS IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 3
Abstract
Background: Chronic idiopathic urticaria (CIU) is widespread symptom of dermatologic diseases. But the etiology is not fully defined. ADA (Adenosine deaminase) ve XO (Xanthine oxidase) are key role in purin metabolism. Cu (Copper), Zn ( Zinc), Se (Selenium) are of vital importance for many proteins and enzymes. Our aim in this study is to investigate these parameters after treatment of CIU patients. Materials and Methods: Blood samples were obtained from 25 patiens with CIU before and after weeks of treatment with H1 –receptor blokers. Blood samples from 10 healthy volunteers were used as controls. ADA, XO, Nitric oxide (NO) and Malondialdehyde (MDA) were measured as spectrofotometric. Also, the levels of trace elements were measured with atomic absorbsion spectroscopy. Results: After treatment Zn, Se levels increased significantly(p<0,05). After treatment, Zn and Se levels approached the control group. (p>0,05) And After treatment MDA, NO, XO, ADA levels significantly decreased (p<0,05). Conclusion: After treatment,Cu, Zn, Se, MDA, NO, ADA,XO approached normal physiological levels.In CIU diesase,purine metabolism and trace element level deteriorate, lipid peroxidation increases.
Authors and Affiliations
Velid Unsal
Keywords
Related Articles
- EP ID EP628889
- DOI -
- Views 142
- Downloads 0
PREDICTORS OF DISEASE PROGRESSION IN IDIOPATHIC DILATED (CONGESTIVE) CARDIOMYOPATHY IN PEDIATRIC AGE
Idiopathic dilated cardiomyopathy (IDCM) is a severe illness which carries a high mortality rate in the pediatric population. In order to characterize IDCM evolution and identifyprognostic predictors in the pediatric car...
SEROPREVALENCE OF HBV, HCV AND HIV AMONG VOLUNTARY BLOOD DONORS AT A TERTIARY HOSPITAL IN BAUCHI, NORTHEASTERN NIGERIA
Background; Blood donation and transfusion are an integral part of effective healthcare delivery and transmissible infections remain a public health problem. Post transfusion infection has its consequential effect on tra...
THE DIAGNOSTIC PERFORMANCE OF PLASMA NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN DETECTING ACUTE KIDNEY INJURY (AKI) IN ADULT CRITICALLY ILL PATIENTS COMPARED WITH CREATININE IN BLOOD
Background: Acute Kidney Injury (AKI) is prevalent among critical illnesses and related with over 50% death. In current practice the detection of AKI is based on elevation of creatinine ≥ 50% from the baseline (RIFLE/AKI...
EFFECT OF CERTAIN POLYMERS ON PHYSICOCHEMICAL PROPERTIES OF TENOXICAM.
Tenoxicam is a widely used non-steroidal anti-inflammatory drug (NSAID). It is practically insoluble in water 14.1mg/ml, it is sparingly soluble in methylene chloride, very slightly soluble in ethanol and dissolves in so...
THE ROLE OF HEALTH EDUCATION IN PROMOTION OF KNOWLEDGE OF BREAST SELF-EXAMINATION
Breast cancer forms the highest percentage of cancer in Sudan (85%). The importance of the study of breast cancer lies in the fact that early detection can maximize the benefits of intervention. One of the most important...