THE EFFECTS OF THE H1-RECEPTOR BLOCKERS ON ADENOSINE DEAMINASE, XHANTHINE OXIDASE AND TRACE ELEMENTS IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 3
Abstract
Background: Chronic idiopathic urticaria (CIU) is widespread symptom of dermatologic diseases. But the etiology is not fully defined. ADA (Adenosine deaminase) ve XO (Xanthine oxidase) are key role in purin metabolism. Cu (Copper), Zn ( Zinc), Se (Selenium) are of vital importance for many proteins and enzymes. Our aim in this study is to investigate these parameters after treatment of CIU patients. Materials and Methods: Blood samples were obtained from 25 patiens with CIU before and after weeks of treatment with H1 –receptor blokers. Blood samples from 10 healthy volunteers were used as controls. ADA, XO, Nitric oxide (NO) and Malondialdehyde (MDA) were measured as spectrofotometric. Also, the levels of trace elements were measured with atomic absorbsion spectroscopy. Results: After treatment Zn, Se levels increased significantly(p<0,05). After treatment, Zn and Se levels approached the control group. (p>0,05) And After treatment MDA, NO, XO, ADA levels significantly decreased (p<0,05). Conclusion: After treatment,Cu, Zn, Se, MDA, NO, ADA,XO approached normal physiological levels.In CIU diesase,purine metabolism and trace element level deteriorate, lipid peroxidation increases.
Authors and Affiliations
Velid Unsal
Keywords
Related Articles
- EP ID EP628889
- DOI -
- Views 161
- Downloads 0
MICROWAVE- ASSISTED SYNTHESIS OF NOVEL CHALCONE DERIVATIVES AND STUDYING OF SOME OF THEIR ANTIMICROBIAL ACTIVITIES
A novel approach for the synthesis of a series of chalcones (3a-f) by the reaction of acetophenones (1a-c) with different aromatic aldehydes (2a-c) as well as barbituric acid (1d) with terphthalaldehyde (2d) under therma...
IMPACT OF CLIMATE CHANGE IN SOUTH ASIA ESPECIALLY IN PAKISTAN
Currently Climate Change is one of the most ignored, overlooked and ongoing manmade disaster. Climate change is no longer an issue for the distant future. It is already taking place in South Asian countries particularly...
DIMETHOATE SELFPOISONING IN A 35-36 WEEK OF PREGNANCY: A CASE REPORT AND LITERATURE REVIEW
Organophosphates (OPs) compounds are a diverse group of chemicals used widely in both domestic and agricultural settings. While the benefits have been considerable, pesticides are responsible for 1 million serious accide...
MONITORING OF RIFAMPICIN RESISTANT TUBERCULOSIS IN NEW AND TREATED PATIENTS IN HODEIDAH, YEMEN BY USING RT – PCR
Background: Rifampicin Resistant Tuberculosis (RR - TB) is detected by using phenotypic or genotypic methods, with or without resistance to other anti-TB drugs. RR is a risk factor poor outcome in tuberculosis. Objective...
NON–ST-ELEVATION MYOCARDIAL INFARCTION (NSTEMI) OUTCOMES IN TYPE 2 DIABETIC PATIENTS WITH NON-OBSTRUCTIVE CORONARY ARTERY STENOSIS: DIABETIC MYOCARDIAL INFARCTION CORONARY NON-OBSTRUCTIVE STENOSIS: DIA-MYCONOS STUDY.
Objective: Management of type 2 diabetic patients (DMT2) with non-obstructive coronary stenosis (NOCS) Non–ST-Elevation Myocardial Infarction (NSTEMI) is unclear. We evaluate the 12-month prognosis of DMT2 with NOCS-NSTE...