THE EFFECTS OF TREATMENT WITH ORAL CONTRACEPTIVE PILL CONTAINING ETHINYL ESTRADIOL-CYPROTERONE ACETATE ALONE OR IN COMBINATION WITH METFORMIN ON CLINICAL, HORMONAL, METABOLIC AND ULTRASONOGRAPHIC CHARACTERISTICS IN POLYCYSTIC OVARIAN SYNDROME
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 32
Abstract
BACKGROUND Poly Cystic Ovary Syndrome (PCOS) is a heterogeneous disorder, characterized by chronic anovulation and hyperandrogenism, which affects between 5 to 10% of women in reproductive age, and it is considered one of the most common endocrine disorders in premenopausal women The objective of this study was to evaluate the effects of 6 months of administration of Oral Contraceptive Pill (OCP) alone or in combination with metformin on clinical, hormonal, metabolic and ultrasonographic characteristics in polycystic ovarian syndrome (PCOS). MATERIALS AND METHODS One hundred and thirty PCOS patients were enrolled in this prospective single blind randomized control trial. PCOS was defined according to the Rotterdam criteria. Patients were randomized to either oral treatment with OCP containing ethinyl estradiolcyproterone acetate alone (n = 66) or OCP in combination with metformin (n = 64). Body Mass Index (BMI), waist circumference (WC), Ferriman–Gallwey (FG) score, luteinizing hormone (LH), total testosterone (TT), lipid levels, fasting insulin, fasting glucose and ultrasonographic parameters such as ovarian volume (OV), follicle number (FN) and ovarian stromal pulsatility index (PI) and resistive index (RI) were measured at baseline and at the end of treatment. RESULTS There was significant reduction in BMI and WC only in the OCP + Metformin group, however the menstrual cycle, serum LH, testosterone and HDL-Cholesterol levels normalized in both groups. Fasting insulin levels reduced significantly only in the OCP + Metformin group. OV and FN were significantly reduced in both the groups and similarly PI & RI values increased in both the groups CONCLUSION We conclude that OCP and metformin should be considered for the treatment of PCOS patients, yet the choice for each drug requires careful consideration of the patient’s clinical characteristics and preference.
Authors and Affiliations
Mahija Sahu, Priyadarshini Tripathy
Keywords
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- EP ID EP570964
- DOI 10.18410/jebmh/2018/485
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