The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes: a randomized double-blinded controlled trial
Journal Title: Electronic Physician - Year 2016, Vol 8, Issue 9
Abstract
BACKGROUND: Despite the certain role of both vitamin D and adiponectin in the regulation of insulin sensitivity, the interaction between these two agents has remained uncertain. OBJECTIVE: The present study aimed to determine whether vitamin D is able to change plasma adiponectin and affect glucose homeostasis and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. METHODS: This randomized clinical trial was conducted at Clinic of Shahid Sadoughi Hospital in Yazd, Iran, from January 25, 2012 to December 25, 2014. In this randomized, double-blinded controlled trial, 64 first-degree relatives of type 2 diabetic patients were assigned randomly to receive either vitamin D supplement (50000 IU vitamin D tablet weekly) plus lifestyle change as the intervention group (n = 32) or placebo plus lifestyle change as the control group (n = 32) for twelve weeks (three months). RESULTS: Fifty-three patients (28 in the intervention group and 25 in the control group) completed the study. Serum levels of vitamin D increased while insulin level and consequently insulin resistance (calculated by HOMA formula) significantly decreased in the case group (p-value <0.001 for all variables). Although the values of these three biomarkers showed a slight increase in control group, the changes were not statistically significant. The levels of the changes in other markers including adiponectin, Fasting Blood Sugar (FBS), triglyceride, and total cholesterol remained insignificant in both study groups after completing interventions compared with before interventions. CONCLUSION: This study showed that decreased insulin resistance is expected by administrating vitamin D supplement in first-degree relatives of the patients with diabetes mellitus. TRIAL REGISTRATION: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the IRCT ID: 201105176430N1. FUNDING: The authors received no financial support for the research or publication of this article
Authors and Affiliations
Mohammadi SM, Eghbali SA, Soheilikhah S, Ashkezari SJ, Salami M, Afkhami-Ardekani M
Keywords
Related Articles
- EP ID EP331528
- DOI 10.19082/2849
- Views 80
- Downloads 0
Components that affect the Implementation of Health Services’ Strategic Purchasing: A Comprehensive Review of the Literature
INTRODUCTION: Strategic purchasing is one of the mechanisms that can increase access, equity, and efficiency as well as the correct management of health resources. The aim of this study was to extract important and influ...
Development of the UTAUT2 model to measure the acceptance of medical laboratory portals by patients in Shiraz
INTRODUCTION: One of the main stages for achieving the success is acceptance of technology by its users. Hence, identifying the effective factors in successful acceptance of information technology is necessary and vital....
Diagnostic value of computerized tomography venography in detecting stenosis and occlusion of subclavian vein and superior vena in chronic renal failure patients
INTRODUCTION: Currently, venography is the standard diagnostic method to examine veins before implementing access, which is invasive in nature. Computerized tomography venography (CTV) can simultaneously indicate deep an...
The story of fake impact factor companies and how we detected them.
Beginning about three years ago, the world of academic publishing has become infected by fake impact factors and misleading metrics that are launched by bogus companies. The misleading metrics and fake impact factors hav...
Effects of Nanoparticles on the Environment and Outdoor Workplaces
Today, most parts of different nanotechnologies are growing and developing without any special rules and regulations. This could result in undesirable changes in the environment and affect workers in indoor and outdoor w...