The Efficacy and Safety of Busulfan-Etoposide-Melphalan Regimen in Autologous Stem Cell Transplantation in Relapsed/ Refractory Hodgkin and Non-Hodgkin Lymphoma Patients: “A Single-Center Experience”
Journal Title: Istanbul Medical Journal - Year 2021, Vol 22, Issue 2
Abstract
Introduction: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard treatment for relapsed and refractory lymphoma patients. The difficulties in accessing and high cost of carmustine have led to the increased use of alternative regimen before ASCT for the treatment of lymphoma, including busulfan-based busulfan-etoposidemelphalan (BuEM) regimens. Methods: Data of 16 Hodgkin’s lymphoma and non-Hodgkin’s lymphoma patients who underwent ASCT following BuEM conditioning regimen were retrospectively analyzed within the scope of the study. Results: The median overall survival and progression-free survival during the 188 day follow-up period were found to be 93.8% and 87.1%, respectively. Neutrophil and platelet engraftment times were found to be 11 and 17 days, respectively, and the median duration of hospitalization was determined to be at 22.5 days. The prevalence of grade 3-4 mucositis was found to be at 37.6% (81.3% in total), whereas that of grade 1-4 infection was 87.5%, and grade 1-3 gastrointestinal system toxicity was found to be at 68.3%. No obvious liver and kidney toxicity were observed. Transplantation-related mortality was detected in 1 (6.25%) patient. Conclusion: Our results suggest that a prospective study on the BuEM regimen involving a large number of cases is required.
Authors and Affiliations
Ali Eser, Ayşen Timurağaoğlu
Keywords
Related Articles
- EP ID EP694383
- DOI 10.4274/imj.galenos.2021.92255
- Views 39
- Downloads 0
Difficult Tracheotomy in Advanced Anaplastic Thyroid Carcinoma
Anaplastic thyroid carcinoma (ATC) is a rare and rapidly progressive malignancy of the thyroid gland with a poor prognosis. The cause of death in these patients is mostly due to invasion of the airway with mass and metas...
Two Different Types of Atypical Kounis Syndrome in the Same Patient at Different Times: A Case Report
Kounis syndrome (KS) is an acute coronary syndrome secondary to allergic reactions and can be triggered by many factors. It is a rare condition that is difficult to diagnose, which delays the prognosis of the disease. KS...
Predictors of Clinically Significant Prostate Cancer: A Comparative Study of PSA, PSA Density, and MRI Parameters
Introduction: The purpose of this study was to compare prostate-specific antigen (PSA), PSA density (PSAd), the prostate imaging-reporting and data system (PI-RADS) score, and lesion dimension (four parameters) in clinic...
Can VAP-1 Protein be used as a Biomarker in Thyroid Cancer?
Introduction: The aim of this study is to determine whether vascular adhesion protein-1 (VAP-1) glycoprotein can be used as a biomarker in thyroid cancer. Methods: Retrospective analysis of the pathology results of pati...
The Effects of Low Dose Zinc Supplementation on the Development of New Bone in Rabbits
Introduction: Zinc (Zn) is an essential element for the healthy bone metabolism. It promotes bone formation by stimulating the proliferation and differentiation of osteoblasts, and increases the stimulation of osteoblast...