The Efficacy and Safety of the Combination of Elbasvir/Grazoprevir In the Treatment of Chronic Hepatitis C Virus Infection: A Systematic Review of Clinical Trials
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 3
Abstract
Elbasvir (EBR) and grazoprevir (GZR) are new direct-acting antivirals for patients with hepatitis C virus (HCV) infection. This systematic review aimed to investigate the efficacy and safety of this dual-drug combination in HCV infection. Four electronic search engines/libraries were systematically searched for relevant publications. Studies were screened for eligibility and data were extracted. Sustained virologic response rate after 12 weeks of treatment (SVR12) and commonly reported outcomes were discussed. The databases search picked up 597 and nine papers were finally included for our study after screening. Included clinical trials were either double-blind or open-label trials. The majority of which are phase III and are part of the C-EDGE trial program. The results of the qualitative synthesis proved the high efficacy of once-daily EBR/GZR 50/100 mg in patients with chronic HCV infection, including difficult to treat populations. Higher SVR 12 was achieved in the different groups in the included clinical trials mainly for HCV genotype1 and genotype 4 infections. EBR/GZR was generally well tolerated in clinical trials. Fatigue was the most common reported adverse event. This study showed that EBR/GZR is an effective new treatment of adults with chronic HCV infections mainly genotype 1 and 4 infection, including the difficult-to-treat patient populations. We recommend further well designed controlled trials to assert upon these results.
Authors and Affiliations
Faisal Ali Almesned, Hamad Mohammed Al Selaimy, Wesam Saeed Zubair Mohammed, Noor Abbas Al –Aithan, Riyadh Mohammed Alshammari, Khalid Mansi Alanazi, Anas Ahmed Almulhem, Mohammed Lafi Alanazi
Keywords
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- EP ID EP531373
- DOI 10.21276/ijmrp.2018.4.3.001
- Views 80
- Downloads 0
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