The Efficacy of Eltrombopag Treatment in Patients who developed Platelet Engraftment Failure after Allogeneic Stem Cell Transplantation: A Single Center Experience
Journal Title: Bezmiâlem Science - Year 2021, Vol 9, Issue 1
Abstract
Objective: Persistent thrombocytopenia is a common complication of allogeneic stem cell transplantation (ASCT). Treatment of platelet engraftment failure after ASCT remains controversial. Drugs, such as eltrombopag, are used for this purpose. Eltrombopag is an Food and Drug Administration -approved oral thrombopoietin receptor agonist. We aim to present the results of 12 patients treated with eltrombopag in our center for severe thrombocytopenia after ASCT. Methods: From January 2018 to February 2020, a total of 56 patients underwent ASCT. Twelve patients had persistent thrombocytopenia following ASCT. All patients received eltrombopag. Results: Primary platelet engraftment failure developed in six of 12 patients who developed persistent thrombocytopenia after ASCT. Secondary platelet engraftment failure developed in six of them. After eltrombopag treatment, eight (66.7%) patients achieved transfusion independence, whereas four patients (33.3%) could not. The maximum platelet count after the eltrombopag treatment was median 118.000 (range: 24,000-253,000)/μL. The median time from the start of eltrombopag until the platelet count was >50,000/ μL was 18 (range: 14-112) days. The median duration of treatment with eltrombopag was 70 (range: 26-180) days. Eltrombopag was discontinued in all patients who survived and had full platelet recovery. Conclusion: Thrombocytopenia after ASCT is a condition that should be treated as it can lead to life-threatening bleeding.
Authors and Affiliations
Ali ESER, Ayşen TİMURAĞAOĞLU
Keywords
Related Articles
- EP ID EP691836
- DOI 10.14235/bas.galenos.2020.5582
- Views 129
- Downloads 0
Analysis of Personal, Environmental, and Occupational Factors Affecting the Activity Performance of Disabled Drivers
Objective: This study was planned to analyse environmental, personal and occupational factors on disabled drivers’ performance who had been driving. Methods: Twenty orthopedically (group II) and 20 neurologically disabl...
Home-based Palliative Care
Palliative care (PC) is defined as the approach that improves quality of lives of patients and their families who face up with the problems accompanied with life-threatening conditions. Provided usually in an inpatient s...
Study Protocol Preparation for Randomized Controlled Trials: Recommendations and Protocol Recording
The World Health Organization (WHO) considers the registration of the study protocol as the publication of an internationally recognized set of information on the design, conduct, and management of clinical trials. Writi...
The Turkish Validity and Reliability of The Physical Activity Self-efficacy Scale For Children
Objective: Purpose of this study is to determine validity and reliability of the Physical Activity Self-efficacy scale for Turkish children (PASSC). Methods: The study was conducted as a methodological epidemiological s...
Effectiveness of Radiofrequency Ablation Therapy in Osteoid Osteoma: Our 5 Years Experience
Objective: To evaluate the results of treatment with computed tomography (CT) guided percutaneous radiofrequency ablation (RFA) for osteoid osteomas (OO) and to evaluate imaging findings. Methods: Sixty-three patients (...