The Efficacy of Infliximab plus Methotrexate in Patients with Active Rheumatoid Arthritis in North of Iraq: 5-Year Extended Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 10
Abstract
Objective: To evaluate the role of infliximab plus methotrexate given for up to 5 years in patients with active longstanding rheumatoid arthritis. Methods: patients responding inadequately to methotrexate and at least one other disease-modifying antirheumatic drug were enrolled into a 24 week, controlled study with infliximab plus methotrexate or placebo plus methotrexate and some were enrolled in a subsequent open label extension. The efficacy were evaluated. Results: Among 250 patients in the original trial, 220 received at least one dose of infliximab and were evaluated. At the time of analysis 160/ 220 (72.7%) patients had remained in the study and received treatment for a mean of 4.5 years. Withdrawals were for lack of efficacy (24%), adverse events (36%), and other reasons(50%). In 160 patients who completed 5 years treatment efficacy achieved of 6 month was maintained at 5 years. 45% achieved clinical remission (DAS28<2.6), and 27% had no physical function abnormalities (HAQ=0). Results were similar for 160 patients who received treatment for 3-5 years. Conclusions: Infliximab plus methotrexate sustained clinical response and remission in patients with rheumatoid arthritis during 5 years
Authors and Affiliations
Dr Niaz Al-Barzinji
Keywords
Related Articles
- EP ID EP214545
- DOI -
- Views 24
- Downloads 0
Bacteriological Profile and Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa in Blood Samples of Septicemia Patients at PRH, Loni Bk. Bk.
Hospital acquired infections occurring secondary to hospitalization are often more dangerous because the bacteria may already be resistant to antibiotics. Research findings have reported that inappropriate treatment of B...
The Association between C- Reactive Protein and Preeclampsia in Late Pregnancy
Objective: To study the association between C-Reactive Protein (CRP) level and preeclampsia in late pregnancy. Patients & Methods: A total 100 pregnant women were enrolled in this study, all at third trimester. Their age...
Acalculous Cholecystitis as a Presentation of Acute Hepatitis B
Acalculous cholecystitis (ACC) as commonly understood, is an inflammation of the gall bladder in the absence of stones. Acute viral hepatitis B though being a systemic infection, predominantly affects the liver but also...
A Rare Case of Peripheral PNET with A Rare Presentation
A 28 year male without any comorbidity having fever since 2 weeks and complex partial seizures since day 1 was presented with altered sensorium with left sided hemiparesis in emergency room and evaluated with MRI Brain w...
A Comparison Study of QT Dispersion in Early and Delayed Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Introduction: In analysis of Global burden of disease there is a shift from communicable to non communicable disease. Ischemic heart disease causes more death and disability than any other illness in the developed world....