The Efficacy Of Milbemycin Oxime In The Treatment Of Naturally Acquired Infestations Of Sarcoptes Scabiei On Dogs
Journal Title: International Journal of Veterinary Health Science & Research (IJVHSR) - Year 2013, Vol 1, Issue 1
Abstract
Milbemycin oxime tablets were evaluated for efficacy against sarcoptic mange mites in naturally infested dogs. Sixty-five dogs were allocated to two groups and were housed individually. Fifty of the dogs were treated orally with milbemycin oxime at the proposed dose. The other fifteen were treated orally with vehicle. Study day 0 was defined as the first day of treatment administration. Dogs were treated on days 0, 7 and 14, and efficacy was assessed by counting viable mites recovered from skin scrapings. To enumerate Sarcoptes scabiei mites, skin scrapings were taken on each of Days-1, 14, 28, 42 and 56. Clinical signs of mange and the extent of sarcoptic lesions were evaluated on each dog when scrapings were made. Evaluation of the efficacy of the treatment was based on the absence of mites supported by the absence of clinical signs associated with canine sarcoptic mange. Treatment with milbemycin oxime at weekly intervals resulted in a rapid reduction of mites and improved clinical signs. Percentage reductions in geometric mean mite counts for milbemycin oxime, compared with vehicle, on days 14, 28, 42, and 56 were 90, 96, 100, and 100%, respectively. The overall cure rates at Day 56, based on zero mite counts and resolution of clinical signs were 100% of dogs. Weekly treatment with maximum dose (2.0g/kg) rate of milbemycin oxime for continually three weeks, was effective against naturally acquired infestations of sarcoptes scabiei in dogs, reducing mites counts by 100%.
Authors and Affiliations
Zhiqiang Shen
Keywords
Related Articles
- EP ID EP327460
- DOI 10.19070/2332-2748-130001
- Views 55
- Downloads 0
Iatrogenic Foreign Body in a Previously Blind Teat: Case Report
Foreign body in the teat cistern was surgically removed by thelotomy
Rumen Evolution of Circadian Physiology: A Pragmatic Science
This article elaborates on discovering circadian rhythmicity of rumen microbial characteristics including pH, osmolarity, volatile fatty acids production and absorption capacity, lactate utilization capability, rumen liq...
Clinical, Biochemical and Bacteriological Investigation of Pneumonia in Calves with Special Reference to Alpha-1-Acid Glycoprotein Response
In order to investigate clinical and biochemical parameters in calves with bovine respiratory disease (BRD), twenty-five Holstein calves with clinical picture of BRD were selected to this investigation. Ten clinically he...
An Innovative Cardiac Biomarker in Veterinary Medicine
An Innovative Cardiac Biomarker in Veterinary Medicine
Replacement of Soybean Meal with Silkworm Meal In The Diets of White Leghorn Layers and Effects on Performance, Apparent Total Tract Digestibility, Blood Profile and Egg Quality
This study elucidated the effects of replacing soybean meal with silkworm meal on production performance, apparent total tract digestibility of nutrients, blood profile, and egg quality traits in white leghorn layers. A...