The Efficacy of N-acetylcysteine Against Renal Oxidative Stress After Extracorporeal Shock Wave Treatment: An Experimental Rat Model
Journal Title: Journal of Urological Surgery - Year 2020, Vol 7, Issue 1
Abstract
Objective: To evaluate effects of renal extracorporeal shock wave lithotripsy (SWL) on plasma Oxidative Stress index (OSI) and to observe histopathological alterations in an experimental model. Secondly, protective role of N-acetylcysteine (NAC) was investigated. Materials and Methods: A total of 24 rats were randomly divided into 3 groups as control (group 1), SWL + saline (group 2), and SWL + NAC (group 3). Study groups were further divided into two subgroups as short-term and long-term. In groups 2 and 3, 2000 shock waves were applied. Intraperitoneal saline was administered in group 2, and intraperitoneal NAC was given to group 3. No treatment was administered to group 1. Blood samples and nephrectomy specimens were obtained for biochemical and histopathological examinations, respectively. OSI was calculated by measuring plasma total antioxidant status (TAS) and total oxidant status (TOS). Acute and chronic histopathological damage were evaluated by light microscopy. Results: SWL caused a remarkable increase in oxidative stress. Strikingly, TOS levels were significantly lower (p=0.027) and TAS levels were significantly higher (p=0.006) in rats with SWL + NAC (group 3). As a result, OSI was lower (p=0.013). This effect was particularly significant in the short-term subgroup. It was also concluded that tubular damage and interstitial inflammation were higher in the SWL group (p=0.022). These acute histological alterations were slighter in rats with NAC. Conclusion: The current study demonstrated that SWL can cause severe oxidative stress and acute renal damage by increasing free oxygen radical production. NAC was effective in decreasing SWL-induced oxidative stress and preventing certain histological alterations to some extent.
Authors and Affiliations
Dursun Baba, Kamil Çam, Yusuf Şenoğlu, Alpaslan Yüksel, Havva Erdem, Ekrem Başaran
Keywords
Related Articles
- EP ID EP685302
- DOI 10.4274/jus.galenos.2019.2941
- Views 162
- Downloads 0
Male Infertility as A Window to Health
no summary
The Effective Way in Answering the IPSS: Patients Themselves or with the Physician?
Objective: This study aimed to compare the answers given to the International Prostate Symptom score (IPSS) questionnaire by patients with the help of a physician according to age and education level. Materials and Meth...
Should the Double-J Stent Be Removed Endoscopically after a Ureteroscopic Stone Surgery?
Objective: Ureterorenoscopic stone surgery (USS) is the primary method of ureteral stone treatment. Double-J (JJ) stenting is an integral part of a USS, and most urologists prefer to use it without an extraction string....
Bladder Sparing Surgical Treatment in a Patient with Pelvic Lipomatosis
Pelvic lipomatosis is an uncommon benign disease characterized by the excessive growth of mature fat tissue in the perivesical and perirectal areas. A 61-year-old male patient, who was admitted with voiding difficulty, u...
Predictive Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Measured Prior to Prostate Biopsy
Objective: We planned to investigate the value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting prostate cancer (PCa). Materials and Methods: We enrolled 302 male patients who...