The Evaluation of Kidney Function in Elderly Individuals Under Renin Angiotensin Aldosterone System Inhibitor Therapy

Journal Title: Journal of European Internal Medicine Professionals (JEIMP) - Year 2023, Vol 1, Issue 2

Abstract

Background: We aim to investigate the impact of hydration status (12-hour fasting or 12-hour water-free fasting) on the estimated glomerular filtration rate (eGFR) and serum potassium in renin-angiotensin-aldosterone (RAAS) blocker users during biochemical assessments. Material and Methods: A total of 90 individuals were enrolled in this longitudinal study. 57 of those were advised to be hydrated for at least 1 L before the next hospital visit. 33 of 90 individuals remained in the non-hydrated group and their blood samples were evaluated following 12-hour fasting. Hypertensive patients were divided according to the antihypertensive medicine group (RAAS blockers, RAAS blockers + diuretics, and others). eGFR, serum potassium, calcium, magnesium, albumin, and glucose levels were compared between hydrated and non-hydrated individuals. Results: The mean age was 48.21±16.59 in hydrated and 47.42±17.12 in non-hydrated groups (p=0.831). Hypertension prevalence was 59.6% in the hydrated group and 54.5% in non hydrated group. In the RAAS blocker users, following hydration, eGFR elevated up to 8-11 ml/dk (p<0.05). In the hydrated individuals with age ≥65 years and receiving RAAS blockers, the increment in eGFR was most prominent (p=0.002). Hydration increased eGFR in individuals with RAAS blockers-free and nonhypertensive, however, those increments were not statistically significant (p>0.05). Similarly, serum potassium levels decreased following hydration in RAAS blocker users (p<0.05). Hyperkalemia (serum potassium ≥ 5 mEq/L) risk decreased from 9.2 fold to 6.16 fold following hydration (p<0.05). Conclusion: Twelve-hour fasting is associated with lower eGFR and higher serum potassium levels. An assessment of eGFR and serum potassium following hydration (12-hour water-free fasting) is beneficial for accurately assessing. This impact is more prominent in RAAS blocker users, especially in individuals ≥65 years.

Authors and Affiliations

Serhat Kucuker, Canan Çiçek Demir, Ramazan Demir, Vedat Gençer

Keywords

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  • EP ID EP714472
  • DOI https://doi.org/10.5281/zenodo.7772719
  • Views 61
  • Downloads 0

How To Cite

Serhat Kucuker, Canan Çiçek Demir, Ramazan Demir, Vedat Gençer (2023). The Evaluation of Kidney Function in Elderly Individuals Under Renin Angiotensin Aldosterone System Inhibitor Therapy. Journal of European Internal Medicine Professionals (JEIMP), 1(2), -. https://europub.co.uk/articles/-A-714472