THE EXPRESSION OF IMMUNOHISTOCHEMICAL MARKERS IN THE FETAL LIVER AFTER MATERNAL EXPOSURE OF LEAD ACETATE AND UNDER THE CORRECTION
Journal Title: Science Review - Year 2017, Vol 7, Issue 7
Abstract
The purpose of the study was to determine the expression of immunohistochemical markers in the fetal lever after lead acetate treatment and under the correction. We used the intact Vistar rat fetuses at 14th, 16th and 18th days of prenatal development, after maternal lead acetate treatment (50 mg/kg) alone and together with lycopene (500 mg/kg) for 3 weeks before pregnancy and during pregnancy. The expression of AE1/AE3, VEGF, MMP-1 and MMP-9 was significantly suppressed by toxicant and slightly corrected. eNOS expression revealed that the small vessels were the most vulnerable with a low potential for the correction. Lead acetate did not change the αSMA expression itself, but the accumulation of αSMA-positive Ito cells was depended on the degree of dystrophic and fibrotic changes in the liver. The expression of WT1 did not reveal the susceptibility to lead acetate, whereas caspase-3 expression increased.
Authors and Affiliations
H. V. Dovhal, M. A. Dovhal, O. A. Romanenko
Keywords
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