The frequency of Y chromosome microdeletions and importance of genetic counselling in infertile male: A metropolis experience
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 9
Abstract
Aim: To study the incidence & type of microdeletions in patient with infertility by Y Microdeletion by Polymerase chain reaction (PCR) studies. Materials and Methods: In 763 patients aged from 21-47 years with suspicion of Y microdeletion PCR based Y microdeletion studies carried. 6-8 ml of peripheral blood was collected in EDTA Vacutainers and the genomic DNA were extracted and analysed by PCR. Results: Microdeletion was observed in 30 patients with a total deletion rate of 3.9%. Of these deletions, AZFc deletions was seen in 2.6%, AZFb deletions in 0.8%, microdeletion of AZFb and AZFc in 3 patients with a deletion rate of 0.4%, 1 patient showed deletion in AZFa, AZFb and AZFc with a deletion rate of 0.1%. Conclusion: Knowing the genetic status of Y chromosome in male infertile individuals currently in the era of advanced assisted reproductive technology (ART) can be very helpful to the couple.
Authors and Affiliations
Shailesh Pande, Pratiksha Chheda, Dollar Goradia, Tavisha Dama, Milind Chanekar, Anurita Pais
Keywords
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