The frequency of Y chromosome microdeletions and importance of genetic counselling in infertile male: A metropolis experience
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 9
Abstract
Aim: To study the incidence & type of microdeletions in patient with infertility by Y Microdeletion by Polymerase chain reaction (PCR) studies. Materials and Methods: In 763 patients aged from 21-47 years with suspicion of Y microdeletion PCR based Y microdeletion studies carried. 6-8 ml of peripheral blood was collected in EDTA Vacutainers and the genomic DNA were extracted and analysed by PCR. Results: Microdeletion was observed in 30 patients with a total deletion rate of 3.9%. Of these deletions, AZFc deletions was seen in 2.6%, AZFb deletions in 0.8%, microdeletion of AZFb and AZFc in 3 patients with a deletion rate of 0.4%, 1 patient showed deletion in AZFa, AZFb and AZFc with a deletion rate of 0.1%. Conclusion: Knowing the genetic status of Y chromosome in male infertile individuals currently in the era of advanced assisted reproductive technology (ART) can be very helpful to the couple.
Authors and Affiliations
Shailesh Pande, Pratiksha Chheda, Dollar Goradia, Tavisha Dama, Milind Chanekar, Anurita Pais
Keywords
Related Articles
- EP ID EP587686
- DOI -
- Views 134
- Downloads 0
Seroprevalence of hepatitis B Surface Antigen and anti-hepatitis C virus in HIV positive patients Ajmer, Rajasthan, India
The aim was to determine the seroprevalence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) and co-infection among Hospital based population in Ajmer Rajasthan. Limited data is available, at Rajasthan state leve...
Serum calcium and magnesium in preeclampsia and normal pregnancy
Preeclampsia affects 3–5% of pregnancies. Along with preeclampsia, other diseases which are included in the group of hypertensive disorders of pregnancy are eclampsia, gestational hypertension and chronic hypertension. T...
A comparison of epidural butorphanol 2mg and fentanyl 75 mcg for postoperative analgesia using combined spinal epidural anaesthesia technique: A randomized double blind clinical study
Objectives: The aim of this study was to assess the effect of Butorphanol & Fentanyl used as epidural analgesic agent in patients undergoing elective Abdomino-Pelvic and lower limb surgeries. Primary Objective is to comp...
Clinical evaluation of administration a single dose of antibiotic in surgical treatment of laparoscopic appendectomy
A single, effective and nontoxic drug is used to prevent infection by a specific microorganism or to eradicate an early infection. Single or multiple dosage regimes of antibiotics will be depending upon the patient resou...
Prevalence of depression, anxiety and stress among male medical students at Najran University, Saudi Arabia
Objectives: The aim of this 2017 study is to identify the prevalence of depression, anxiety, and stress and their association with Najran university male medical students’ age, monthly income, living status, academic lev...