The genetics of melonoma
Journal Title: Postępy Dermatologii i Alergologii - Year 2006, Vol 23, Issue 1
Abstract
Melanoma is an important public health issue and research strategies are trying to elucidate the relative contribution of genes and environmental factors in its causation. In terms of genetic factors the discovery of cell cycle genes – CDKN2a, CDK4 – has been a great advance. Current studies aim to identify other susceptibility genes and to determine the interactions of the various genetic and environmental factors. Among them, MC1R (Melanocortin-1 receptor gene), PTEN, BRAF, NRAS are being analysed more closely. Epistatic (gene-gene) and gene environmental interactions studies aim to recognize individuals at high risk.
Authors and Affiliations
Urszula Brudnik, Anna Wojas-Pelc, Wojciech Branicki
Keywords
Related Articles
- EP ID EP118312
- DOI -
- Views 81
- Downloads 0
The genetics of melonoma
Melanoma is an important public health issue and research strategies are trying to elucidate the relative contribution of genes and environmental factors in its causation. In terms of genetic factors the discovery of cel...
Lichen planus bullous treated with acitretin and PUVA therapy: a case report
Lichen planus bullous is a rare variant of lichen planus with characteristic clinical, histological and immunopathological features in which a lichenoid eruption is found in association with bullae on both involved and a...
Disorders of immunological balance between Th1 and Th2 cells and the role of chosen cytokines in atopic dermatitis
Atopic dermatitis (AD) is one of the most common diseases in children. This article presents current views on immunological mechanisms that take place in pathogenesis of AD. The role of disturb differentiation of T helpe...
List do redakcji
The problem of eosinophilia in chronic urticaria
The main purpose of the present study was to analyze peripheral blood eosinophilia phenomenon in patients suffering from chronic urticaria with regard to particular elements of patients’ examination as well as severity o...