The Glutathione S-Transferase Activities in the Evaluation Acute Viral Hepatitis B and Chronic Alcoholic Liver Disease
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 23, Issue 5
Abstract
Glutathione S-Transferase is an important hepatic detoxifying enzyme. Half-life of GST alpha in plasma is about1hr; its concentration follows the changes in the hepatocellular damage more rapidly than aspartate amino transferase (AST) or alanine amino transferase (ALT). Aim and Objectives: To validate chronic alcoholic liver disease and acute viral hepatitis B could produce any significant changes in serum glutathione S-transferase activities. Materials and Methods: A total of 120 samples were used in the present research. 20 hepatitis B patient 40 chronic alcoholic hepatitis patients and 60 age and sex matched control subjects. Serum GST activity and standard LFT (Liver Function Test) parameters done. Results: GST activity showed a significantly increase (p value< 0.001) in chronic alcoholic liver disease patients (22.293±4.159 IU/L vs 20.127±4.789 IU/L) and in acute viral hepatitis (23.685±6.751 IU/L vs 20.127±4.789 IU/L). In multiple logistic regression analysis when GST measurement was added to a LFT, the diagnostic significance increased from R2=0.792 to 0.884 in acute viral hepatitis B and from R2= 0.843 to 0.849 in chronic alcoholic cirrhosis. Standard LFT parameters are significantly different in both groups. Area under ROC (Receiver Operative Characteristic Curve) is 0.952 for model having albumin+ ALT which is increased to 0.992 after addition of GST in previous model in acute viral Hepatitis B. While in alcoholic Hepatitis Area under ROC is 0.966 for model having albumin+ ALT which is increased to 0.974 after addition of GST in previous model. Conclusion: GST activity may provide additional LFT measurement to the current battery of tests to differentiate acute hepatitis B and alcoholic liver disease from normal population and may improve the evaluation of Hepatitis B virus and alcoholic cirrhosis when added to routine LFT parameters.
Authors and Affiliations
S. D. Sawant, M. R. Mogarekar
Keywords
Related Articles
- EP ID EP312357
- DOI 10.9734/JAMMR/2017/35540
- Views 74
- Downloads 0
An Overview of Hutchinson Gilford Progeria Syndrome (HGPS)
Hutchinson Gilford Progeria Syndrome (HGPS) is a rare genetic disorder. The disorder is characterized by premature aging, generally leading to death. The purpose of this article is to review Hutchinson Gilford Progeria S...
A Study on Dental Health Behavior of Nursing Students in Western University
Aims: The aim of this study was to assess the knowledge, attitude and practice of oral health among undergraduate Thai nursing students in Western University in Faculty of Nursing at Kanchanaburi, Thailand. Study Design:...
Structure of the Small Intestinal Mucosa after Acute Hemorrhagic Shock and Reperfusion of the Ischemic Limbs
Aims: The purpose of the report is to study Structure of the Small Intestinal Mucosa after Acute Hemorrhagic Shock and Reperfusion of the Ischemic Limbs. Place and Duration of Study: The Department of Histology and Medic...
A Rare Case of IgA-mediated Autoimmune Hemolytic Anemia in a Young Adult
A 21-year-old previously healthy male presented with unexplained intravascular hemolysis. Patient had anemia, elevated serum indirect bilirubin, elevated LDH, reticulocytosis, decreased haptoglobin and spherocytosis. Ini...
An Evaluation of Risk Factors for Cerebral Palsy in Children in Jos, Nigeria
Aim: To evaluate the incidence of risk factors for cerebral palsy (CP) in children at Jos University Teaching Hospital, Jos, North-Central Nigeria. Study Design: This was a case control study. Place and Duration of Study...