The hypoglycemic effects of a hydro-alcoholic extract from Securigera securidaca seeds on induced diabetic in male rats <br /> <br />
Journal Title: مجله دانشگاه علوم پزشکی شهرکرد - Year 2007, Vol 8, Issue 4
Abstract
Background and aim: Diabetes mellitus is a metabolic disorder of carbohydrates, lipids and proteins caused by deficiency or lack of insulin. The side effects of chemical drugs have increased the requirement to use of medical plants with fewer complications than that of the chemical drugs. Securigera securidaca is one of the medical plants traditionally used. This medicine has antiepileptic, diuretic, hypotensive and hypoglycemic effects. This study was aimed to evaluate the hypoglycemic effect of hydro-alcoholic extract of S. securidaca seeds on streptozocine induced diabetic rats. Methods: In this experimental study, a total of seventy Wistar albino male rats were randomly divided into seven groups. Diabetes was induced via intravenous injection of streptozocine (45mg/kg). Then, the extract of Securigera securidaca seed was administrated orally in dosage of 500, 1000 and 2000 mg/kg in the mice. The blood glucose was measured before and one, two and three weeks after the administration of the extract. Using statistical methods, (Student t test, paired t test and ANOVA), the data were analyzed. Results: Compared with the control group, Streptozocine significantly increased the blood glucose of the test group (p
Authors and Affiliations
ezadpanah Gheitasi, mouhamadreza Nikbakht, haybatollah Sadeghi , vida Sabzali, sohylla Sabzali, mehrdad Shahrani
Keywords
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