The Imiquimod Induced Psoriatic Animal “Model: Scientific Implications
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 13, Issue 1
Abstract
Psoriasis is a chronic inflammatory auto-immune disease, which causes serious skin lesions, acanthosis and parakeratosis, leaving a long-lasting detrimental influence on our appearances and life quality. Though a huge scientific information regarding psoriasis-related mechanism and pathological analysis is getting accumulated over the last decades in the price of valuable experiments and efforts of many experts. However, an absence of reliable mouse model has been a major obstacle to further advances in psoriasis research. Recently, a topical application of imiquimod (IMQ), classical Toll-like Receptor (TLR)-7 agonist, has provided a strong foundation of psoriasis study on the animal model as it stimulates cutaneous phenotype similar to human psoriasis in the mouse. IMQ-mediated skin inflammation often exhibits slight divergences on human psoriasis and extensive investigations to yield more suitable psoriatic model are taking place. In this review, we summarized the recent novel breakthroughs on improving existing IMQ model and discovering a new model of psoriasis and discussed their importance on psoriasis research.Imiquimod (IMQ), hallmark ligand of Toll-like Receptor (TLR)-7 in mouse and TLR7/8 in human has been known to be protective against human papilloma virus-caused warts, actinic keratosis and basal cell carcinomas. Due to its small chemical structure and lipophilicity, it is really suitable for topical administration, thus successfully used as an ointment for the aforementioned diseases [1,2]. Sooner IMQ treatment appeared to be a reason for psoriasis for people who are prone to psoriasis. Since the first article of IMQ-induced mouse inflammatory model was published in 2009, it emerged as one of the most prominent animal models in psoriasis study as scientist have adopted this model to their research practice and experiments. The long-term topical administration of IMQ on skin ear or shaved back skin results psoriasis-like skin inflammation, characterized by increased skin erythema and scaling, thickened epidermis, alteration of keratinocytes differentiation and recruitment of immune cells to skin, mimicking psoriatic pathogenesis in human [3,4].
Authors and Affiliations
Banzragch Dorjsembe, Jung Yeob Ham, Jin Chul Kim
Keywords
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- EP ID EP587515
- DOI 10.26717/BJSTR.2019.13.002347
- Views 188
- Downloads 0
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