The impact of HIV and malaria co-infection on apolipoprotein profile and CD4+ T cell counts in adult HIV seropositives in Nauth Nnewi, South Eastern, Nigeria.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 3
Abstract
Aim: To determine the impact of HIV and malaria co-infections on Apolipoproteins and CD4+ T cell counts in adult HIV seropositives in NAUTH Nnewi, South Eastern, Nigeria. Methods: A total of 400 subjects aged between 17 and 58 years were recruited from patients that attended HIV Clinic, NAUTH, Nnewi for this study. The study design was a case-control study. Ethical approval was obtained from the Ethics Review Committee from NAUTH, Nnewi. The subjects were grouped based on WHO criteria for staging HIV infection and the presence or absence of malaria. Turbidimetric procedure was used forA-I, A-II, B, C-II, C-III and Apo E and Cyflow SL-Green for CD4 counts. Student t test was used for data analysis. Results: The mean serum levels of Apo C-III and Apo E were significantly higher in symptomatic HIV on ART with malaria parasitaemia compared with those without malaria parasitaemia at (P< 0.05 respectively). But the mean blood CD4 count was significantly lower in symptomatic HIV on ART with malaria infection compared to those without malaria infection(p<0.05). Also, the mean serum levels of Apo C-II and Apo E were significantly higher in symptomatic HIV not on ART with malaria parasitaemia compared with those without malaria parasitaemia at (P< 0.05 respectively).Also, the serum Apo E level was significantly higher in asymptomatic HIV subjects with malaria parasitaemia compared with those without malaria parasitaemia(p<0.05). Conclusion: Malaria endemicity poses a threat to the improved apolipoprotein status in HIV malaria co-infection.
Authors and Affiliations
Ifeoma P. Ezeugwunne 1*, Charles C. Onyenekwe 2 , Emmanuel C. Ogbodo3 , Rebecca C. Chukwuanukwu3 , Nancy N. Njoku-Oji4 , Rosemary A. Analike2 , Victor N. Oguaka1 ,Akuma K. Amah5 , Joseph E. Ahaneku2 , Gladys. Ahaneku6 .
Keywords
Related Articles
- EP ID EP563360
- DOI 10.22192/ijcrms.2018.04.03.008
- Views 127
- Downloads 0
Pain experience and perception of pain management among post operative patients Imo state University teaching hospital Orlu
This study aimed at assessing pain experience and perception of pain management among post operative patients in Imo State University Teaching Hospital Umuna, Orlu Local Government Area; Imo State. Pain is a subjective a...
A study of five years trend of Case fatality rate of leptospirosis in a tertiary care hospital in Mumbai, India
Background: Leptospirosis, a zoonosis associated with potentially fatal consequences, has long been a grossly under reported disease in India. There has been a sudden rise in the number of leptospirosis cases in the year...
Pendulum appliance and its modifications - A review
Molar distalization is procedure used to move permanent molars distally in the arch. Distalization in maxillary arch is more common and easy than mandibular arch because maxillary bone has more trabecular bone where as m...
Acute and Sub-acute Toxicity Studies of Omavanni Chenduram
Toxicity study is the study of adverse effects of chemical and physical agents and the degree to which a substance can harm human or animals. The present study reveals the acute and sub-acute toxicity studies of Omavanni...
Addicts' Viewpoint of the Reasons for Relapse (Case Study: Methadone Maintenance Treatment center of Assalouyeh)
In general, prevention of risk factors for addiction relapse is a multi-dimensional program that with its implementation in future can prevent from relapse in the addicts under treatment and in addition to eliminating th...