The impact of HIV and malaria co-infection on apolipoprotein profile and CD4+ T cell counts in adult HIV seropositives in Nauth Nnewi, South Eastern, Nigeria.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 3
Abstract
Aim: To determine the impact of HIV and malaria co-infections on Apolipoproteins and CD4+ T cell counts in adult HIV seropositives in NAUTH Nnewi, South Eastern, Nigeria. Methods: A total of 400 subjects aged between 17 and 58 years were recruited from patients that attended HIV Clinic, NAUTH, Nnewi for this study. The study design was a case-control study. Ethical approval was obtained from the Ethics Review Committee from NAUTH, Nnewi. The subjects were grouped based on WHO criteria for staging HIV infection and the presence or absence of malaria. Turbidimetric procedure was used forA-I, A-II, B, C-II, C-III and Apo E and Cyflow SL-Green for CD4 counts. Student t test was used for data analysis. Results: The mean serum levels of Apo C-III and Apo E were significantly higher in symptomatic HIV on ART with malaria parasitaemia compared with those without malaria parasitaemia at (P< 0.05 respectively). But the mean blood CD4 count was significantly lower in symptomatic HIV on ART with malaria infection compared to those without malaria infection(p<0.05). Also, the mean serum levels of Apo C-II and Apo E were significantly higher in symptomatic HIV not on ART with malaria parasitaemia compared with those without malaria parasitaemia at (P< 0.05 respectively).Also, the serum Apo E level was significantly higher in asymptomatic HIV subjects with malaria parasitaemia compared with those without malaria parasitaemia(p<0.05). Conclusion: Malaria endemicity poses a threat to the improved apolipoprotein status in HIV malaria co-infection.
Authors and Affiliations
Ifeoma P. Ezeugwunne 1*, Charles C. Onyenekwe 2 , Emmanuel C. Ogbodo3 , Rebecca C. Chukwuanukwu3 , Nancy N. Njoku-Oji4 , Rosemary A. Analike2 , Victor N. Oguaka1 ,Akuma K. Amah5 , Joseph E. Ahaneku2 , Gladys. Ahaneku6 .
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- EP ID EP563360
- DOI 10.22192/ijcrms.2018.04.03.008
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- Downloads 0
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