The Impact of Low-Grading Inflammation on Circulating Endothelial-Derived Progenitor Cells in Patients with Metabolic Syndrome and Diabetes Mellitus
Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 4
Abstract
Type-2 Diabetes Mellitus (T2DM) remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating Endothelial Progenitor Cells (EPCs) in T2DM patients in comparison with MetS subjects. Methods: The study retrospectively evolved 101 patients (54 subjects with T2DM and 47 patients with MetS) and 35 healthy volunteers. The flow cytometry was used for predictably distinguishing cell subsets, which depend on expression of CD45, CD34, CD14, Tie-2, and VEGFR2. Biomarkers were measured at baseline of the study. Results: Patients with MetS have demonstrated lower incidence of dyslipidemia, lower concentrations of HbA1c, fasting blood glucose, insulin, and LDL-C when compared with T2DM subjects. Higher HDL-C and HOMA-IR were found in T2DM patients than in MetS subjects. There is a significant difference between the medians of absolute numbers and frequencies of CD14+CD309+ and CD14+CD309+Tie2+ in healthy volunteers and patients with dysmetabolic disorders respectively. CD14+CD309+ and CD14+CD309+Tie2+ subsets of circulating EPCs were determined in higher concentration among MetS subjects in comparison with T2DM patients. Osteoprotegerin (OPG) and hs-C-reactive protein (CRP), improve significantly predictive model based on T2DM + number of multiple cardiovascular risk factors (MCRFs) >3 for decreased both angiopoetic phenotypes of circulating EPCs. Conclusion: we suggest that inflammatory biomarkers (hs-CRP, OPG) may consider statistically significant predictors for decreased EPCs labeled CD14+CD309+ and CD14+CD309+Tie2+ among dysmetabolic patients without preexisting atherosclerotic lesions of coronary arteries.
Authors and Affiliations
Alexander E Berezin, Alexander A Kremzer, Tatyana A Berezina, Martovitskaya Yu. V
Keywords
Related Articles
- EP ID EP333247
- DOI 10.15226/2374-6890/2/4/00126
- Views 86
- Downloads 0
Increased Plasma Glucose Level after 1 Hour of Challenge in The Oral Glucose Tolerance Test (OGTT) as an Indicator of Pre-Diabetes
The oral glucose tolerance test (OGTT) is performed in patients in whom abnormalities of glucose metabolism are suspected, but the criteria for diagnosing diabetes are not yet met. It is also routinely carried out in the...
Effect of Age, Gender and Season on Thyroid Hormones Status in Children of East Delhi- A Hospital Based Study
Background: Thyroid hormones are the most commonly prescribed tests in the clinical set up. Variations are observed in individuals of different age, sex, race and nutritional status. However few studies describe these ch...
Reproductive Dysfunction from the Stress of Exercise Training is not Gender Specific: The “Exercise-Hypogonadal Male Condition”
Investigative studies point to participation in exercise training as having significant detrimental effects upon reproductive hormonal profiles in men. Specifically, men chronically exposed to training for endurance spor...
Social Representations of Feeding People with Type-2 Diabetes Mellitus
The aim of this study was to analyze the social representations of the diets 34 patients of the Brazilian public primary care service diagnosed with type- 2 diabetes mellitus, according to how they represent their identi...
Factors Associated With Glycemic Control among Type 2 Diabetes Patients Attending Mathari National Teaching Hospital, Nairobi Kenya
Introduction: Type 2 Diabetes mellitus is chronic metabolic disorder characterized by hyperglycemia resulting from insulin secretion, insulin action, or both and accounts for over 95% cases globally. Uncontrolled diabete...