The Impact of Low-Grading Inflammation on Circulating Endothelial-Derived Progenitor Cells in Patients with Metabolic Syndrome and Diabetes Mellitus
Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 4
Abstract
Type-2 Diabetes Mellitus (T2DM) remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating Endothelial Progenitor Cells (EPCs) in T2DM patients in comparison with MetS subjects. Methods: The study retrospectively evolved 101 patients (54 subjects with T2DM and 47 patients with MetS) and 35 healthy volunteers. The flow cytometry was used for predictably distinguishing cell subsets, which depend on expression of CD45, CD34, CD14, Tie-2, and VEGFR2. Biomarkers were measured at baseline of the study. Results: Patients with MetS have demonstrated lower incidence of dyslipidemia, lower concentrations of HbA1c, fasting blood glucose, insulin, and LDL-C when compared with T2DM subjects. Higher HDL-C and HOMA-IR were found in T2DM patients than in MetS subjects. There is a significant difference between the medians of absolute numbers and frequencies of CD14+CD309+ and CD14+CD309+Tie2+ in healthy volunteers and patients with dysmetabolic disorders respectively. CD14+CD309+ and CD14+CD309+Tie2+ subsets of circulating EPCs were determined in higher concentration among MetS subjects in comparison with T2DM patients. Osteoprotegerin (OPG) and hs-C-reactive protein (CRP), improve significantly predictive model based on T2DM + number of multiple cardiovascular risk factors (MCRFs) >3 for decreased both angiopoetic phenotypes of circulating EPCs. Conclusion: we suggest that inflammatory biomarkers (hs-CRP, OPG) may consider statistically significant predictors for decreased EPCs labeled CD14+CD309+ and CD14+CD309+Tie2+ among dysmetabolic patients without preexisting atherosclerotic lesions of coronary arteries.
Authors and Affiliations
Alexander E Berezin, Alexander A Kremzer, Tatyana A Berezina, Martovitskaya Yu. V
Keywords
Related Articles
- EP ID EP333247
- DOI 10.15226/2374-6890/2/4/00126
- Views 92
- Downloads 0
Resistant Hypertension in Diabetes Mellitus
Diabetes Mellitus (DM) confers an increase of cardiovascular risk, independently from other conventional risk factors. The risk of cardiovascular events is 4-fold higher in patients with both diabetes and hypertension, c...
Beneficial Effects of a 1-Year Lifestyle Intervention on Metabolic Abnormalities in Overweight and Obese Schoolchildren in Sousse Tunisia: A Pre-Post Quasi- Experimental Study with Control Group
Introduction: The prevalence of obesity in children has increased worldwide during the most recent decades. In this context, we have conducted this study in the purpose to investigate changes in metabolic syndrome in ove...
Assessing Real World Effect of Laparoscopic Bariatric Surgery on Healthcare Costs- a Retrospective Matched Cohort Study using a U.S. Administrative Claims Database
Background: Bariatric surgery is considered an efficacious procedure for stimulating significant weight loss and improving obesity-related co morbidities among severely obese persons; however, the effect of bariatric sur...
Long Term Medical Treatment of Congenital Hyperinsulinemic Hypoglycemia
Background: Hyperinsulinism is the most common cause of recurrent hypoglycemia in early infancy. Surgical treatment with partial/near total pancreatectomy has been the mainstay of treatment but does not result in complet...
Pentraxin 3 as A Cardiovascular Marker in Primary Hyperparathyroidism
Aim: Pentraxin 3 (PTX3) is an acute-phase glycoprotein, which is increased in patients with cardiovascular disease (CVD) and considered as a predictor of CVD in the general population. Accumulating evidence suggests that...