The Impact of Low-Grading Inflammation on Circulating Endothelial-Derived Progenitor Cells in Patients with Metabolic Syndrome and Diabetes Mellitus

Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 4

Abstract

Type-2 Diabetes Mellitus (T2DM) remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating Endothelial Progenitor Cells (EPCs) in T2DM patients in comparison with MetS subjects. Methods: The study retrospectively evolved 101 patients (54 subjects with T2DM and 47 patients with MetS) and 35 healthy volunteers. The flow cytometry was used for predictably distinguishing cell subsets, which depend on expression of CD45, CD34, CD14, Tie-2, and VEGFR2. Biomarkers were measured at baseline of the study. Results: Patients with MetS have demonstrated lower incidence of dyslipidemia, lower concentrations of HbA1c, fasting blood glucose, insulin, and LDL-C when compared with T2DM subjects. Higher HDL-C and HOMA-IR were found in T2DM patients than in MetS subjects. There is a significant difference between the medians of absolute numbers and frequencies of CD14+CD309+ and CD14+CD309+Tie2+ in healthy volunteers and patients with dysmetabolic disorders respectively. CD14+CD309+ and CD14+CD309+Tie2+ subsets of circulating EPCs were determined in higher concentration among MetS subjects in comparison with T2DM patients. Osteoprotegerin (OPG) and hs-C-reactive protein (CRP), improve significantly predictive model based on T2DM + number of multiple cardiovascular risk factors (MCRFs) >3 for decreased both angiopoetic phenotypes of circulating EPCs. Conclusion: we suggest that inflammatory biomarkers (hs-CRP, OPG) may consider statistically significant predictors for decreased EPCs labeled CD14+CD309+ and CD14+CD309+Tie2+ among dysmetabolic patients without preexisting atherosclerotic lesions of coronary arteries.

Authors and Affiliations

Alexander E Berezin, Alexander A Kremzer, Tatyana A Berezina, Martovitskaya Yu. V

Keywords

Related Articles

Normocalcemic Primary Hyperparathyroidism

The prevalence and the natural history of Normocalcemic Primary Hyperparathyroidism (NCHPT) are not well known. Therefore the aim of this retrospective study was to determine the prevalence and natural history of (NCHPT)...

Emotional Intelligence is Associated with Blood Level Glucose: A Brief Report

Preliminary evidence associate aspects of emotion regulation and effective management of emotion-driven behavior with health outcomes in general and diabetic outcomes in particular. This study examined this association i...

Diabetic Lower Extremity Ulcers and Hyperbaric Oxygen Therapy

Diabetic wounds are a worldwide problem with significant effects for those whose wounds fail to heal as expected and who go on to require amputation. Standard care is generally effective in healing diabetic ulcers, but i...

Medical Management of Acute Foot Injury in Diabetic Patients

Diabetic foot is the main cause of hospitalization in diabetic patients and the most common cause of lower extremity amputation. Infection and ischemia are the main risk factors for major amputation and death in case of...

Recent Insights into Treatment of Non-Alcoholic Steatohepatitis

Non-Alcoholic Fatty Liver Disease (NAFLD) represents a major public health issue worldwide. The main characteristic of NAFLD is the accumulation of lipids in hepatocytes to form lipid droplets. The spectrum of NAFLD rang...

Download PDF file
  • EP ID EP333247
  • DOI 10.15226/2374-6890/2/4/00126
  • Views 93
  • Downloads 0

How To Cite

Alexander E Berezin, Alexander A Kremzer, Tatyana A Berezina, Martovitskaya Yu. V (2015). The Impact of Low-Grading Inflammation on Circulating Endothelial-Derived Progenitor Cells in Patients with Metabolic Syndrome and Diabetes Mellitus. Journal of Endocrinology and Diabetes, 2(4), 1-8. https://europub.co.uk/articles/-A-333247