The Impact of PRAME Expression on Breslow Depth in Melanoma Arising in Dysplastic Nevi in a Large Multi-State Dermatology Group
Journal Title: Journal of Dermatology Research - Year 2024, Vol 5, Issue 2
Abstract
Background: PRAME immunohistochemistry has been reported to be positive in at least 83.2% of invasive melanomas while being positive in no more than 13.6% of benign nevi. Melanoma may arise within pre-existing nevi or dysplastic nevi and PRAME could potentially have an effect on the measured Breslow depth. Objective: We performed a retrospective review of invasive melanoma cases diagnosed over a 4 year period to evaluate if the use of PRAME had an impact on Breslow depth. Methods: Diagnostic reports were reviewed to separate out cases of invasive melanoma that arose in precursor nevi or dysplastic nevi. The final sample size is 152 cases. Results: The average melanoma depth in the PRAME group was 0.51 mm, while being 0.68 mm in the no PRAME group (p<0.05). The pathologic stage was unchanged in all cases. Limitations: The pathology reports were made by multiple dermatopathologists and therefore reporting of precursor nevi on the reports may not be entirely uniform. Conclusion: PRAME does impact the Breslow depth of invasive melanoma when arising in precursor nevi, but significant alterations in the pathologic stage were not observed.
Authors and Affiliations
Brevin McCool, Antonio Ray, Michael Hatch, Cary Chisholm
Keywords
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- EP ID EP741619
- DOI https://doi.org/10.46889/JDR.2024.5207
- Views 17
- Downloads 0
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