The Importance of Baseline Screening Investigations and Modified Severity Weighted Assessment Tool in Patients with Early Stage Mycosis Fungoides: A Four-year Retrospective Study
Journal Title: Türk Dermatoloji Dergisi - Year 2019, Vol 13, Issue 1
Abstract
Objective: The present study aims to evaluate the prognosis and response to treatment relationship of baseline clinical and hematological parameters including eosinophil counts, neutrophil/lymphocyte ratio, levels of lactate dehydrogenase (LDH) and beta-2 microglobulin, flow cytometry and initial modified Severity Weighted Assessment Tool (mSWAT) scores in patients with mycosis fungoides (MF). Methods: Medical records of 112 patients with the diagnosis of early-stage MF were examined retrospectively. Data of the patient and disease characteristics, and baseline laboratory tests were reviewed and evaluated in terms of stage and treatment response. Results: In this study, patients were classified into two groups: responders and non-responders. Complete and partial responses were observed in 79 (70%) patients. Eight patients (7%) developed relapse in the follow-up period. In the staging groups (IA, IB, IIA), the frequency of elevated beta-2 microglobulin was different among all parameters. When the results were compared based on clinical responsiveness, until the time to diagnosis was significantly longer in non-responder patients than responders. High mSWAT scores, elevated beta-2 microglobulin and LDH levels, and plaque-type lesions were more frequent in non-responder patients. Conclusion: Our study demonstrates that extensive screening tests may not be very meaningful in patients with early-stage MF. mSWAT scores, beta-2 microglobulin, and LDH tests should be evaluated as useful measurements in prediction the response to treatment.
Authors and Affiliations
Pınar İncel Uysal, Neslihan Akdoğan, Mesude Falay, Buket Şahin, Gülsüm Özet, Başak Yalçın
Keywords
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