The importance of magnification chromoendoscopy with methylene blue in detecting specialized intestinal metaplasia in short segment Barrett’s esophagus
Journal Title: Human & Veterinary Medicine - International Journal of the Bioflux Society - Year 2012, Vol 4, Issue 1
Abstract
Background:S pecialized intestinal metaplasia (SIM) is not identifiable in Barrett esophagus in standard white light endoscopy. In this study we assessed the utility of magnification chromoendoscopy with methylene blue in detecting SIM in patients with short Barrett’s esophagus.Material and method: The study included 50 patients with suspected short Barrett’s esophagus: 26 followed standard endoscopy with random biopsies and 24 underwent magnification chromoendoscopy with methylene blue with targeted biopsies. In the magnification chromoendoscopy group, magnified images were analyzed and specific patterns were classified using Endo’s classification. Results: In the standard endoscopy group, 17 of 26 patients were detected as having SIM and in the magnification chromoendoscopy group 20 of 24 patients were SIM positive. Magnification chromoendoscopy increases the probability of detecting SIM up to 2,4 times (OR=2.39, p=0.028). Sensitivity and specificity of MB staining in diagnosis of SIM was 78.7% and 55.5%. SIM was diagnosed in areas with tubular and villous patterns, but had a significant correlation only with villous pattern (p=0.017).Conclusion: Magnification chromoendoscopy with methylene blue improves SIM detection in patients with short Barrett’s esophagus.
Authors and Affiliations
Ofelia Pascarenco, Daniela Dobru, Olga Brusnic, Danusia Onişor, Mircea Stoian, Ghenadie Pascarenco, Marinela Găleanu
Keywords
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