The importance of pharmacogenetic tests in evaluation of the effectiveness of methotrexate treatment in rheumatoid arthritis (part 1)
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
Methotrexate (MTX) is still the gold standard in the treatment of rheumatoid arthritis and is used worldwide in more than 0.5 million patients with RA. Much hope is currently associated with the individualization of therapy provided to RA patients. The search is underway for biochemical and clinical markers that would be useful in predicting good response to MTX therapy. Along with clinical factors, genetic predisposition may also be helpful. Polymorphism of genes participating in MTX metabolism may affect the drug’s efficacy and the rate of adverse effects. Pharmacogenetic studies may contribute to more effective individualization of therapy for RA patients. There are many potential enzymes and transport proteins present in polymorphic forms, which are involved in transport of MTX into the cell, its metabolism and elimination from the cell. There is a chance that in the future through individualized therapy we will be able to customize therapy (type of drug, dose, route of administration) to the molecular subtype of the disease and the genotype of the patient. Patients with a specific type of polymorphism would require more frequent monitoring of the efficacy and safety of treatment. Note, however, that genetic predisposition is only one of the factors contributing to differences in pharmacotherapy in individual patients.
Authors and Affiliations
Jerzy Świerkot, Ryszard Ślęzak
Keywords
Related Articles
- EP ID EP66456
- DOI -
- Views 152
- Downloads 0
Związki między reumatoidalnym zapaleniem stawów i przewlekłym zapaleniem przyzębia
Chronic periodontitis is an infectious disease associated with the progressive destruction of periodontal tissues. In recent years, more and more data indicate an existing relationship between periodontal disease and rhe...
Immunology of the eye
The eye is an organ of sight characterized by unusual immunological properties, resulting from its anatomical structure and physiology, as well as the presence of specific elements that, through the mechanisms of innate...
Celery – cause of severe anaphylactic shock
Background: We present a case of anaphylactic shock induced by celery ingestion in a 28-year old woman with pollinosis during allergen (50% birch, 50% grass) immunotherapy. Case Report: A female patient, aged 28 was adm...
Statyny i astma
Statyny należą do leków powszechnie stosowanych w leczeniu hiperlipidemii oraz chorób układu sercowo-naczyniowego. Hamując aktywność reduktazy 3-hydroksy-metyloglutarylo-koenzymu A (HMG-CoA) zmniejszają syntezę cholest...
Witamina D – nowe spojrzenie w medycynie i reumatologii
Badania ostatniego dziesięciolecia wykazały udział witaminy D nie tylko w procesach metabolicznych kości, ale również w procesach immunologicznych i antykancerogennych. Powszechnie występujące niedobry tej witaminy wiążą...