The Inappropriate Photoreceptor Depolarization May Give Rise to Age-Related Macular Degeneration: Clinical Evidence
Journal Title: Journal of Ophthalmology and Advance Research - Year 2025, Vol 6, Issue 1
Abstract
Age-related Macular Degeneration (AMD) is a complex, multifactorial, progressive retinal disease that affects millions of people worldwide. Alterations in phototransduction, renewal of the outer segments of photoreceptors, visual transduction and retinol metabolism have a major impact on retinal health. Mutations within any of the molecules responsible for these visual processes cause different types of degenerative retinal diseases. Increase in membrane potential caused by accidental binding to a foreign molecule, increased temperature or ocular pressure could trigger an electrochemical overload in the photoreceptor which would be inappropriately depolarized. The signs of this process are clearly visible with Optical Coherence Tomography (OCT): hyper-reflective vertical lines that cross the choroid at the points of interruption of the ellipsoid zone resulting in atrophy and compromise of the outer hematoretinal barrier. The occasional finding of these lines would represent the first clinical sign of a degenerative process which could subsequently give rise to those events characterizing AMD.
Authors and Affiliations
Fabrizio Magonio1*
Keywords
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- EP ID EP759392
- DOI https://doi.org/10.46889/JOAR.2025.6105
- Views 12
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