The Incidence of Virological Success and Its Independent Predictors Following A Short Course of HAART among HAART Naïve HIV Positive Pregnant Women in Nnewi
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Background: Highly active anti-retroviral therapy (HAART) is introduced to HIV pregnant women to reduce their viral load and increase their CD4 count; this reduces the risk of mother to child transmission of HIV. Viral load is use to monitor the success of HAART. Aim: To study the incidence of Virological Success, and its independent predictors following a short course of HAART among HAART naïve HIV positive pregnant women. Study Design and Setting: This is prospective longitudinal study carried out at Nnamdi Azikiwe University Teaching Hospital, Nnewi, South East, Nigeria between January 1st , 2017 and December 31st, 2017. Methodology This is a prospective longitudinal study in which HAART naive HIV positive pregnant women, who presented to the Antenatal clinic of NAUTH, Nnewi were recruited and followed up till delivery. Baseline viral load prior to initiation of HARRT were obtained, and recorded. During labour, (at least after 4 weeks of HARRT therapy) another sample of blood was collected for a repeat viral load. Univariate analysis (Odds ratio and chi-square) was used to analyse the factors associated with virological success and P-value of <0.05 was considered statistically significant. Logistic regression was used to identify the independent predictors of virological success. Result :Forty-two (52.5%) had virological success. Adherence (Adj OD= 7.198, P=0.014), long therapy (Adj OD = 9.018, P=0.008) and immunological success (Adj OD = 6.413, P =0.018) were independent predictors for virological success. Conclusion: The virological success is fairly high among HAART naïve HIV positive pregnant women following a short period of HAART. Adherence, long period of therapy, and immunological success were independent predictors of virological success.
Authors and Affiliations
Okolie VE, Obiechina NJA, Ikpeze OC, Obi Nwosu Betrand, Umeononihu OS
Keywords
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- EP ID EP572154
- DOI 10.9790/0853-1804031620.
- Views 65
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