The indexes of osteogenic stem cells activity in patients with rheumatoid arthritis and frontal knee deformities
Journal Title: Orthopaedics, Traumatology and Prosthetics - Year 2018, Vol 610, Issue 1
Abstract
Objective: to study the indexes of stem cells activity of bone marrow which form knee joint (lateral and medial parts of distal femur and proximal tibia part) which were cut at arthroplasty surgery in patients with rheumatoid arthritis and frontal knee deformity. Methods: spongiest bone was taken at surgery (knee arthroplasty) from medial and lateral sides of distal femur and proximal tibia. Due to cloning method of fibroblast colony forming units we studied in 37 patients with rheumatoid arthritis of knee joint. We studied 168 samples of bone marrow, 204 cultures of stem cells were growth. Results: we observed significant deceleration of reparative process in bone tissue at rheumatoid arthritis. Significant difference of fibroblast colony forming units in 1 sm 3 volume in different parts of knee joint was observed. In the medial femur condylar this index was (0,2307 ± 0,16) · 104, it exceeds values obtained in other areas in 11–20 times. It was shown that stem cells of the lateral tibia condylar had worse conditions for regenerative potential in cases of valgus deformity compare with varus. There were 4 times less amount of fibroblast colony forming units and the efficacy of its cloning was 2.6 times lower. Conclusion: significant differences were revealed in the indexes of osteogenic activity of stem cells which form knee joint (lateral and medial parts of distal femur and proximal tibia part).
Authors and Affiliations
Lesya Panchenko, Yevgen Avtomeenko, Andrey Babko, Sergey Gerasimenko, Vera Polishko
Keywords
Related Articles
- EP ID EP555667
- DOI 10.15674/0030-59872018141-46
- Views 184
- Downloads 0
TENODESIS OF LONG BICEPS TENDON IN IT’S PATHOLOGY
One of the causes of pain and dysfunction of the shoulder joint may be inflammation or injury of intraarticular or extraarticular part of long head of the biceps (LHB). Different versions ofLHB pathology are the indicati...
THE EFFECTIVENESS OF THE DIFFERENT SCHEMES OF COMPLEX CONSERVATIVE TREATMENT OF ANIMALS WITH INDUCED KNEE ARTHRITIS
The effectiveness of conservative treatment in patients with knee joint arthritis can be enhanced through the use of the linked pharmacological and physical factors. The possibility of comprehensive use of low-intensity...
Effect of bone canal widening after anterior cruciate ligament reconstruction [Эффект расширения костных каналов после реконструкции передней крестообразной связки]
One of the complications after anterior cruciate ligament reconstruction is widening of bone canals after surgery, it can lead to slow integration of the graft with bone, promotion of secondary instability and revision r...
Functional spine analysis at surgical treatment of burst fractures of thoracic and lumbar spine [Аналіз функціонального стану хребта за умов хірургічного лікування вибухових переломів грудного та поперекового відділів]
Burst fracture — is traumatic injury under the influence of high-energy axial compression which results multifragmentary vertebrae fracture with penetration of bone fragments into spine canal and paravertebral tissues. O...
[Эндопротезирование головки лучевой кости биполярным бесцементным эндопротезом с парой трения металл – металл]
Objective: to review technical peculiarities of designed uncemented modular radial head endoprothesis and to analyze it clinical application in patients with fractures and dislocations of the radial head ІІІ–IV types by...