The influence of carrageenan on markers of endogenous intoxication in rats
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 3
Abstract
Background: The growth of the world population and the need to increase food production led to the widespread use of food additives. One of such additives is carrageenan. Potentially negative health effects of carrageenans prompt us to question safety of their widespread use. Aims and Objectives: In this study, we defined the effect of carrageenan (E407) consumption on the main markers of endogenous intoxication in rats. Materials and Methods: Experimental studies were conducted on 72 non-linear, female, white rats weighing 150-180 g. The experimental animals had free access to 0.5% carrageenan solution in drinking water. Control group of animals received pure water. Syndrome of endogenous intoxication was evaluated using measurements of low, medium, and high molecular weight substances in blood plasma, red blood cell suspension, and urine. Results: Our results indicate shift of the markers of intoxication syndrome toward mainly catabolic substances. The results obtained after 1 week of the experiment correspond with phase of partial compensation, characterized by increased concentrations of low and middle molecular weight substances in red blood cells and plasma. After 2 weeks and up to 1 month of the experiment, the predominantly catabolic markers of endogenous intoxication continue to increase in erythrocytes and plasma, indicating a shift to the phase of partial decompensation to systems and organs of detoxification. Conclusion: The consumption of carrageenan with drinking water in concentration of 0.5% was associated with the development of excessive levels of low and middle molecular weight substances with reduced ability of kidneys to excrete toxic products.
Authors and Affiliations
Мariya Marushchak, Inna Krynytska, Oksana Kopanytsia, Larysa Tupol, Iryna Savchenko, Lyudmyla Mazur
Keywords
Related Articles
- EP ID EP487161
- DOI 10.5455/njppp.2017.7.0517017082017
- Views 64
- Downloads 0
A comparative study of effect of cold pressor test on heart rate between healthy offspring with and without parental history of Type 2 diabetes mellitus
Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. There is an increased susceptibility to develop the d...
Frequency domain analysis of heart rate variability in young obese adults with parental history of hypertension during isotonic exercise: A comparative study
Background: Heart rate variability (HRV) is the beat-to-beat variation in time of consecutive heartbeats. It is one of the indicators of autonomic nervous system (ANS) function. The ANS control of the cardiovascular syst...
A comparative study of skeletal muscle fatigue in diabetic and non-diabetic human beings
Background: Diabetes mellitus has now emerged as a global cause of concern. Fatigue is a widespread and persistent complaint among diabetics. It is associated with a decreased ability to manage day to day activities. Mus...
A study on antidepressant-like effect of dihydroxy flavones in mice and their mechanisms involved
Background: In the treatment of depression, drugs with a quick onset of action and high margin of safety are intensely being searched. Previous studies indicate flavonoids as a potential source for such drugs. Hence, in...
Comparison of visual evoked potential changes with the duration of Type 2 diabetes mellitus
Background: Many studies proved that the visual evoked potential (VEP) nerve conduction studies in the diabetes mellitus (DM) patients helped to detect the early changes in nerve conduction. But with relation to the dura...